ITMCTR2200005813Not yet recruiting未知
Effect of compound Salvia miltiorrhiza dropping pills on improving coronary microcirculation disorder in diabetic patients
Ruijin Hospital affiliated to Shanghai Jiaotong University0 sitesStarted: TBDLast updated:
Conditions
Trial Snapshot
- Phase
- 未知
- Status
- Not yet recruiting
- Sponsor
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional study
Eligibility Criteria
- Ages
- 18 to 75 (—)
- Sex
- All
Inclusion Criteria
- •1) Age =18 and =75, male or female.
- •2) The left anterior descending coronary artery microcirculation resistance index (IMR) =25 was examined by pressure guide wire.
- •3) Have been diagnosed with type 2 diabetes or meet the diagnostic criteria for type 2 diabetes.
- •4) Combined with chest tightness, chest pain, palpitation, shortness of breath and other typical or atypical angina symptoms.
- •5) Coronary angiography showed no severe epicardial coronary artery stenosis (diameter stenosis rate <50%).
- •6) The patient agrees to participate in this study.
Exclusion Criteria
- •Subjects that meet any of the following criteria will be excluded from this study:
- •1) Severe cardiac insufficiency (LVEF<40%).
- •2) Atrioventricular block and bronchial asthma above II°.
- •(3) Malignant hypertension (SBP=200 mmHg and/or DBP=120 mmHg) or severe hypotension (SBP < 90 mmHg).
- •4) Acute myocarditis, pericardial disease, valvular heart disease, primary cardiomyopathy, myocardial infarction, severe left ventricular hypertrophy (ventricular wall or septum thickness =13mm).
- •5) Familial hypercholesterolemia.
- •6) Multiple arteritis.
- •7) Heart stenting was performed within 3 months.
- •8) Coronary artery bypass grafting.
- •9) History of stroke within six months, history of intracranial diseases (aneurysm, arteriovenous malformation), history of extensive trauma or surgery within six weeks;
- •10) Active bleeding, anemia of moderate or higher severity, including known thrombocytopenia or leukopenia, severe liver or kidney dysfunction, uncontrolled infection, immune system and connective tissue diseases.
- •11) those who are pregnant or lactation, or have the intention to give birth within one year, or take effective contraceptive measures during their childbearing years.
- •12) Abnormal liver function (serum ALT level exceeding 3.0 times the upper limit of normal) or abnormal kidney function (eGFR=30%).
- •13) Other respiratory, digestive, blood, infectious, immune, endocrine, neuropsychiatric, tumor and other diseases of clinical significance, which may cause serious risks to patients.
- •14) Patients requiring warfarin or NOAC anticoagulation treatment are taking K channel opening agents and Traditional Chinese medicine preparations for promoting blood circulation and removing stasis to improve microcirculation.
- •15) Allergic to contrast agent or CDDP;
- •16) Life expectancy less than one year;
- •17) Patients who participated in other TCM clinical studies within 12 months prior to inclusion.
Investigators
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