This study looks at how well a major vein (IVC) can predict low blood pressure after spinal anesthesia and how its related to blood flow measures like perfusion and Pleth variability indexes.

Not yet recruiting

• Conditions: Medical and Surgical,

• Registration Number: CTRI/2025/06/089870
• Lead Sponsor: GMC Amritsar

Brief Summary

Spinal anaesthesia is the most common modality for patients undergoing infraumbilical surgeries. Hypotension is the most common complication, which can be avoided by early prediction of fluid status of the patients and optimizing it. The present study was  conducted in the Department of Anaesthesia and Intensive care, Government medical college, Amritsar after approval from institutional thesis and ethics committee. 100 patients will be randomized into 2 groups of 50 each on the basis of inferior vena cava compressibility index noted using ultrasound before giving spinal anaesthesia with a cutoff of 40%. Group A with inferior vena cava compressibility index <40% and Group B inferior vena cava compressibility index >40%. Spinal anaesthesia will be administered to all patients and co-loading will be done with ringer lactate. Haemodynamic monitoring of heart rate, diastolic blood pressure, systolic blood pressure, mean arterial pressure, peripheral oxygen saturation (spo2), and electrocardiography along with perfusion index and pleth variability index will be done. The primary objective of the study will be to assess the efficacy of inferior vena cava compressibility index with hypotension and its sensitivity and specificity in predicting hypotension. Secondary objectives will be total amount of  doses of vasopressor used, side effects and complications and to see the correlation of perfusion index and pleth variability index with inferior vena cava compressibility index in predicting hypotension.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2025-06-29
• Study Start: 2025-10-07

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

American society of anaesthesiology (ASA) GRADE I-II Elective infraumbilical surgeries under spinal anaesthesia.

Exclusion Criteria

• Total number doses of vasopressor given to treat hypotension.
• Correlation of Perfusion index and Pleth variability index with hypotension.
• Any side effects and complications.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To assess the correlations of Inferior Vena Cava compressibility index (IVC	baseline ,followed by every 1 minute till 10 minutes,than every 5 minutes till 40 minutes ,followed by every 10 minutes till 60 minute
CI) with hypotension.	baseline ,followed by every 1 minute till 10 minutes,than every 5 minutes till 40 minutes ,followed by every 10 minutes till 60 minute
To calculate sensitivity and specificity of Inferior Vena Cava compressibility	baseline ,followed by every 1 minute till 10 minutes,than every 5 minutes till 40 minutes ,followed by every 10 minutes till 60 minute
index in predicting hypotension.	baseline ,followed by every 1 minute till 10 minutes,than every 5 minutes till 40 minutes ,followed by every 10 minutes till 60 minute

Secondary Outcome Measures

Name	Time	Method
Total number of doses of vasopressor given to treat	hypotension.

Trial Locations

Locations (1)

Guru Nanak Dev Hospital ,Amritsar; 🇮🇳 Amritsar, PUNJAB, India

Guru Nanak Dev Hospital ,Amritsar

🇮🇳Amritsar, PUNJAB, India

Dr Navpreet kaur ghotra

Principal investigator

8271167890

Navpreetnav67890@gmail.com