Postprandial Effects of Functional Bread
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of Bergen
- Enrollment
- 12
- Locations
- 1
- Primary Endpoint
- area under the curve of postprandial glucose
Study Overview
Brief Summary
This study investigates whether bread with added galactomannan, a soluble fiber, can reduce the postprandial glucose response in healthy overweight adults.
Detailed Description
This single-blind crossover-designed study wants to investigate the postprandial effect of functional bread in healthy overweight adults. Therefore, four types of bread, consumed by the participants, have added galactomannan in different amounts and viscosities, and one bread is the control bread.
The participants arrive after an overnight fast and before the consumption of bread, a fasting blood sample is taken.
After the ingestion, blood samples are taken at specific times. The area under the curve of the postprandial glucose is expected to differ between the functional breads.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Basic Science
- Masking
- Single (Investigator)
Eligibility Criteria
- Ages
- 18 Years to 60 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •healthy, overweight adults (BMI between 25 and 30 kg/m2)
Exclusion Criteria
- •Known diagnosis of diabetes mellitus type 2
- •HbA1c at screening ≥ 48 mmol/mol
- •Other chronic diseases (heart disease, cancer) within the last 3 years
- •Pregnancy and lactation
- •Known drug or alcohol abuse
- •Unwilling to follow the study requirements
Arms & Interventions
Control Bread
no added guar gum
Intervention: Functional bread (Dietary Supplement)
Functional Bread 1
10% guar gum, low molecular weight
Intervention: Functional bread (Dietary Supplement)
functional Bread 2
10% guar gum, high molecular weight
Intervention: Functional bread (Dietary Supplement)
Functional Bread 3
15% guar gum, low molecular weight
Intervention: Functional bread (Dietary Supplement)
Functional Bread 4
15% guar gum, high molecular weight
Intervention: Functional bread (Dietary Supplement)
Outcomes
Primary Outcomes
area under the curve of postprandial glucose
Time Frame: 180 minutes
Secondary Outcomes
- area under the curve postprandial insulin(180 minutes)