Pilot study: Is concomitant administration of lidocaine during oxaliplatin infusion able to prevent pain as a result of oxaliplatin induced acute neuropathy?
- Conditions
- PijngeneeskundeOxaliplatin induced nerve pain10017991
- Registration Number
- NL-OMON42676
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 24
Subjects with stage II to IV colorectal adenocarcinoma, who are scheduled to receive 6-8 cycles of oxaliplatin 130 mg/m2 every 3 weeks.
Receiving other chemotherapeutics in medical history
Allergy to amide type of local anesthetics
Recent myocardial ischemia (<6 months)
Cardiale arrhytmias
Renal function disorders (MDRD < 60)
Liver failure (bilirubine >1,5x upper limit of normal)
Adequate hematologic parameters
Hypokaliemia
Pregnancy or lactating
Use of anti-arythmic drugs (flecainide)
Pre-existing form of neuropathy (polyneuropathy or small fibre neuropathy)
History of chronic pain and opioid use
Risk factors for CIPN: alcoholism, diabetes mellitus
No written informed consent by patient
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Difference in NRS before and after the first oxaliplatin infusion</p><br>
- Secondary Outcome Measures
Name Time Method
Related Research Topics
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