NCT01198808
Unknown
Not Applicable
Prospective Characterization of Tumor-specific T-cell Immunity in Muscle-invasive Bladder Cancer and Its Correlation With Clinical Parameters
Technical University of Munich1 site in 1 country50 target enrollmentAugust 2010
ConditionsBladder Cancer
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Bladder Cancer
- Sponsor
- Technical University of Munich
- Enrollment
- 50
- Locations
- 1
- Last Updated
- 14 years ago
Overview
Brief Summary
Bladder cancer is generally susceptible to immunotherapeutic measures. The investigators will characterize 40 patients with muscle-invasive bladder cancer regarding the existence and frequency of tumorspecific T-cells and regulatory T cells. The found data will be correlated to clinical data such as the cancer-specific survival and the response to chemotherapy.
It is hypothesized that those patients with a high number of Tregs and no tumor-specific T-cells have a worse prognosis.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Histologically confirmed muscle-invasive urothelial carcinoma
- •Age \> 18 years
- •Hemoglobin \> 10g/dl
- •Signed Informed Consent
- •Karnofsky index \< 70%
Exclusion Criteria
- •Clinically relevant second malignancy
- •Severe comorbidities (e.g. NYHA III, end-stage renal disease)
- •Chronic infectious disease (HIV, Tuberculosis)
- •Immunosupression
- •Severe psychiatric diseases
- •Blood donation in the last 4 weeks
Outcomes
Primary Outcomes
Not specified
Study Sites (1)
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