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Clinical Trials/NCT04971486
NCT04971486
Completed
Not Applicable

Effects of Feedback on Learning of a Motor Sequence Task and Resting State Connectivity

University of South Carolina1 site in 1 country33 target enrollmentApril 1, 2021
ConditionsAdult

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Adult
Sponsor
University of South Carolina
Enrollment
33
Locations
1
Primary Endpoint
Response Time
Status
Completed
Last Updated
4 years ago

Overview

Brief Summary

Feedback delivered during motor practice can help promote motor skill learning, enhance confidence, and alter brain connectivity. However, the optimal way to provide feedback to promote learning, confidence and brain connectivity is unknown. This project will study how the feedback that is provided during practice of a movement skill can help people learn and build confidence and whether these correspond to changes in brain function. The investigators will measure motor skill performance, confidence, and resting state brain connectivity before and after a session of motor practice.

Detailed Description

Positive social comparative feedback, which indicate to the learner that they are performing above average, is one way to enhance a learner's expectancies about future performance. Expectancies include the learners' perceived competence about their ability to perform the task, expectations about task outcome (success or failure), and predictions of extrinsic reward or positive experiences related to performance. Positive feedback during motor practice enhances expectancies, which is hypothesized to be rewarding to the learner, leading to better skill performance and learning. Reward is a powerful shaper of behavior. However, while social comparative feedback supports motor skill learning, it is unclear whether positive social comparative feedback induces a response in the dopamine reward network. Therefore, the purpose of this study is to determine the effects of social comparative feedback during motor practice on the functional connectivity of the reward neural network. The study aims to recruit 40 participants who will be randomized into 1 of 2 feedback groups (performance feedback or performance plus positive feedback). Participants will practice a motor sequence task on a single day and then return for retention performance testing about 24 hours later. Measures of brain function and brain structure will be collected before and after practice on day 1. Changes in performance (response time to complete a sequence) and self-efficacy will be measured from baseline to 24 hours later at retention. Changes in brain functional connectivity over practice on day 1 will be assessed in the reward network and the motor network.

Registry
clinicaltrials.gov
Start Date
April 1, 2021
End Date
January 10, 2022
Last Updated
4 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Jill Stewart, PT, PhD

Associate Professor

University of South Carolina

Eligibility Criteria

Inclusion Criteria

  • Age 18 to 40 years
  • Right-hand dominant

Exclusion Criteria

  • Medical diagnosis or medication that affects dopamine (e.g. dopamine reuptake inhibitors)
  • Musculoskeletal issues that limit upper extremity movement
  • Contraindications for magnetic resonance imaging (MRI)

Outcomes

Primary Outcomes

Response Time

Time Frame: Change from baseline to retention at 24 hours

Time to complete one sequence

Task Confidence

Time Frame: Change from baseline to retention at 24 hours

Self-reported confidence in ability to complete a sequence in a given time on a scale of 0 to 10 with a 10 equating to higher confidence

Brain Connectivity

Time Frame: Change from baseline to immediately after practice

Resting state connectivity between pairs of brain regions

Secondary Outcomes

  • Perceived Competence(Change from baseline to immediately after practice)
  • Peak Velocity(Change from baseline to immediately after practice)
  • Total Path Distance(Change from baseline to immediately after practice)
  • Time to Peak Velocity(Change from baseline to immediately after practice)
  • Positive Affect(Change from baseline to immediately after practice)
  • Task Confidence(Change from baseline to immediately after practice)
  • Perceived Interest/Enjoyment(Change from baseline to immediately after practice)
  • Response Time(Change from baseline to immediately after practice)
  • Brain Structure(Baseline assessment)

Study Sites (1)

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