A randomised control trial of mild opioids versus strong opioids for post-discharge analgesia following orthopaedic fracture surgery

Phase 4

Completed

• Conditions: Pain; Fracture; Orthopaedic Surgery; Injuries and Accidents - Fractures; Anaesthesiology - Pain management

• Registration Number: ACTRN12616000941460
• Lead Sponsor: Professor Ian Harris

Brief Summary

Treatment with strong opioids was not superior to treatment with mild opioid medications for treatment of pain in surgically managed orthopaedic fracture patients sub-acutely. Results do not support ongoing strong opioid use following discharge from hospital. Further research to assess suitability of non-opioid treatments and larger multi-centre trials may be warranted.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-07-15
• Study Completion: 2017-11-18
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

Orthopaedic fracture of a long bone (humerus, radius, ulna, femur, tibia or fibula) or the pelvis, patella, calcaneus or talus requiring surgical fixation.

Exclusion Criteria

- Pathological fractures
- Multi-system trauma injuries (major head, chest or abdominal injuries)
- Major infection following surgery
- Opioid dependency

Study & Design

• Study Type: Interventional
• Study Design: Not specified