Clinical and Biological Markers of Response to Cognitive Behavioural Therapy for Depression
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 41
- 试验地点
- 2
- 主要终点
- Montgomery Asberg Depression Rating Scale
研究概览
简要总结
The purpose of this study is to locate clinical markers (for example, interviews, questionnaires, and computer tasks) and biological markers (for example, physiological, blood-based, or electroencephalography measurements) that predict response to cognitive behavioral therapy for depression.
详细描述
Forty adult outpatients with major depressive disorder or persistent depressive disorder will receive up to 20 sessions of cognitive behavioral therapy for depression over 16 weeks. Participants will complete clinical measures (interviews, questionnaires, and computer-based tasks) and biological measures (blood tests, physiological measurements, electroencephalography ) before, during, and after treatment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical diagnosis of Major Depressive Disorder or Persistent Depressive Disorder according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition
- •Must be fluent in English
- •Must be capable to give informed consent
排除标准
- •Lifetime diagnosis of Schizophrenia, Schizoaffective Disorder, Bipolar Disorder
- •Current Alcohol or Drug Use Disorder (except tobacco or caffeine)
- •Current psychotic symptoms
- •Acute suicide risk
- •Psychological treatment for depression initiated during the past three months
- •Pharmacological treatment for depression initiated/changed during the past three months
- •Previous non-response to two or more adequate trials of pharmacotherapy
- •Current significant neurological disorder, head trauma, or unstable medical conditions.
结局指标
主要结局
Montgomery Asberg Depression Rating Scale
时间窗: 16 weeks
Depression symptom severity
次要结局
- Beck Depression Inventory (BDI)(16 weeks)
- Work and Social Adjustment Scale (WSAS)(16 weeks)
- Hamilton Depression Rating Scale (Ham-D)(16 weeks)
- Quick Inventory of Depressive Symptomatology (QIDS)(16 weeks)
- World Health Organization Quality of Life Short Version (WHOQOL-BREF)(16 weeks)
研究者
Lena Quilty
Independent Scientist
Centre for Addiction and Mental Health