Clinical Outcomes of Cyclosporine Eye Drops in Management of Herpetic Keratitis
- Conditions
- Outcomes of Cyclosporine Eye Drops in Herpetic Keratitis
- Interventions
- Registration Number
- NCT05720715
- Lead Sponsor
- Farwaniya Hospital
- Brief Summary
Objective: To compare the additive effect of topical cyclosporine A 0.05% eye drops to prednisolone eye drops, with topical prednisolone acetate 1% eye drops alone in treatment of herpetic stromal keratitis.
Methods: Patients diagnosed with herpetic stromal keratitis are randomly divided into 2 groups; Group A: receive cyclosporine eye drops together with prednisolone eye drops.
Group B: receive topical prednisolone with placebo eye drops (tear replacement).
The 2 groups receive systemic acyclovir therapeutic dose 400 mg five times daily, which then tapered to twice daily prophylactic dose after one month of treatment. Follow up for patients is scheduled as a weekly visit for a duration of 2 months.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 30
- Patients diagnosed with herpetic stromal keratitis
- associated ocular diseases, DM, renal disease, pregnancy, breast feeding.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description group A cyclosporine A 0.05% eye drops receive cyclosporine eye drops together with prednisolone eye drops. group B cyclosporine A 0.05% eye drops receive topical prednisolone with placebo eye drops (tear replacement).
- Primary Outcome Measures
Name Time Method duration of ttt 3 months duration of treatment until complete resolving of keratitis
- Secondary Outcome Measures
Name Time Method improvement in visual acuity 3 months by snellen chart
Trial Locations
- Locations (1)
Farwanyia Hospital
🇰🇼Al Farwānīyah, Farwanyia, Kuwait