Diagnostic Accuracy of Pancreatic Stone Protein in Predicting Severe Outcome in Patients With Peritonitis at the Intensive Care Unit
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 137
- 试验地点
- 1
- 主要终点
- Localization of Peritonitis
研究概览
简要总结
The purpose of this study is to determine the diagnostic accuracy of Pancreatic Stone Protein (PSP) in predicting patient outcomes with suspected peritonitis in the Intensive Care Unit after abdominal surgery and compare PPS with other blood parameters, including C-Reactive Protein (CRP), White Cell Count (WCC), Interleucin-6 (IL-6) and Procalcitonin (PCT).
详细描述
Peritonitis is a severe complication after abdominal surgery. Patients admitted at the Intensive Care Unit (ICU) following surgery bear the risk of localized infection, sepsis or septic shock. Prevention or early detection of such events is important to intervene with an appropriate therapeutic action and avoid risking a potentially life-threatening situation. White blood cell counts (WCC) and C-Reactive Protein (CRP), Interleucin-6 (IL-6) and Procalcitonin (PCT) have all been promising parameters, however, they are useful only in selective cases and have a limited diagnostic accuracy.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Abdominal surgery.
- •Admission to the Intensive Care Unit (ICU).
- •Blood sampling within 3 hours from admission to the ICU
- •Patient over 18 years of age
排除标准
- •Patients already treated for peritonitis.
- •Patients referred from other hospitals with suspicion of peritonitis
- •Patient age less than 18 years of age.
结局指标
主要结局
Localization of Peritonitis
时间窗: up to 2 months
Localised vs. diffused. A clinical finding intra-operatively and/or radiologically (i.e. CT or MRI)
次要结局
未报告次要终点
研究者
Antje Wiede
Investigator
University of Magdeburg