Evaluation of the effects of Fasting Mimicking Diet (FMD) Combined with a Low-Sugar Diet on lipid profile, glycemic, inflammatory and histologic indices in Non-Alcoholic Fatty Liver (NAFLD): a randomized control trial

Shahid Beheshti University of Medical Sciences0 个研究点目标入组 75 人开始时间: 待定最近更新: 2022年5月2日

试验速览

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•General desire to participate in the study
•Age 50-30 years
•- Has evidence of non-alcoholic steatohepatitis and CAP score more than 263
•Body mass index (BMI) = 25kg / m2
•No history of alcohol consumption
•Lack of other diseases and chronic and acute liver disorders (hepatitis B, C, etc.), biliary disease, known autoimmune diseases and hereditary disorders affecting the condition of the liver (iron, copper and ... )
•No pregnancy or breastfeeding in women
•Do not take hepatotoxic drugs such as phenytoin, amoxifen and lithium
•Do not take antibiotics for more than a week during or before the study period
•Do not consume Milk thistle(Silybum marianum)
•Lack of chronic inflammatory disease
•No history of cancer
•Lack of treatment with anti-inflammatory drugs
•Lack of recent weight loss diet
•Blood pressure less than 90/160 mmHg
•No kidney disease (GFR greater than 60 or creatinine between 7-1.4)
•No weight loss of more than 8% in the last 6 months
•Do not use weight loss drugs (chemical drugs and effective herbal products)

•Changes in medications (lipid-lowering drugs, blood sugar control drugs, and blood pressure medications) during the study period
•Lack of adherence to the diet given to patients
•Take supplements or substances that change the individual effect of the diet during the intervention.

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