Effect of Cell Therapy on knee Osteoarthritis

Phase 2

Recruiting

• Conditions: ostheoarthritis.; Osteoarthritis of knee

• Registration Number: IRCT20180102038184N1
• Lead Sponsor: Oroumia University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 14 January 2019

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 5

Inclusion Criteria

1. Have grade 2-4 knee osteoarthritis
2. They have been taken Corticosteroids and NSAIDs for a long time, but due to its side effects , they are not able to take these group of pills.
3. Although Corticosteroids and NSAIDs have been taken for 3 months, significant improvement has not been observed in sense of pain.
4. Being in the range of 18- 85- year-old

Exclusion Criteria

1. There are have blood diseases, cancers, AIDS, and hepatitis.
2- Taking Immunosuppressive drugs for the last 6 months; NSAIDs, ASA within 7 days ago; Plavix, Warfarin within 3 days ago.
3- Tobacco users.
4- Being pregnant or breastfeeding mothers
5 - Have immune system disease
6 - BMI less than 30
7 - Susceptible to lidocaine and epinephrine
8 - Have other joint disease, such as chondrocalcinosis, rheumatoid arthritis, gout, fibromyalgia, lupus,…
9- Have a knee joint surgery up to a year ago
10 - Have arthritis in the pelvis, shoulder...
11 - Unable to tolerate the pain without taking pain killer pills for 5-7 days before each medical visit.

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Score of signs and sypmtomes of knee osteoarthritis according to koos (Knee injury and Osteoarthritis Outcome Score) questionnaire. Timepoint: 1,3,6 months after and 1 year after. Method of measurement: Magnetic Resonance Imaging (MRI) , Knee injury and Osteoarthritis Outcome Score (KOOS).