Research into the causes, diagnostics and course of diseases of the autonomic nervous system
- Conditions
- Diseases of the autonomic nervous system
- Registration Number
- DRKS00028279
- Lead Sponsor
- niklinik RWTH AachenKlinik für Neurologie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 20
1. age between 18 - 60 years (register: at least 18 years old).
2. written declaration of consent
3. persons who are legally competent and mentally capable of
to follow the instructions of the study personnel
4. healthy persons
OR:
Patients with POTS, hypermobile or classic EDS,
SFN or PAF/AAN
(Diagnosis made in the ANS outpatient clinic on the basis of the
clinical examinations including autonomic
function testing and skin biopsy)
Exclusion of other causes (including by means of
cranial MRI and basic laboratory).
5. in all POTS, EDS and PAF/AAN patients at least the following examinations have been performed in clinical routine in the last 6 months before inclusion in the ProANS study or will be completed otherwise
completed (will not be added to the registry!)
- Quantitative sensory testing (QST)
- skin biopsy
- Blood sampling (noradrenaline, adrenaline and specific
antibodies)
- Tilt table (KT) incl. heart rate analysis
- Quantitative sensorimotor axon reflex testing
(QSART)
1. pregnancy (anamnestic, not in the register)
2. minority
3. pacemaker (HSM) or deep brain stimulation (TSH)
(exclusion for electrophysiological examinations)
(not in the registry)
4. moderate and severe sensorimotor
polyneuropathy (not in the registry)
5. other neurodegenerative diseases such as Parkinson's,
Alzheimer's disease or inflammatory diseases such as multiple
sclerosis (not in the registry)
6. severe heart failure (not in registry)
7. diabetic rentinopathy (exclusion for Valsalva
maneuvers, not in registry)
8. poorly controlled diabetes mellitus (not in the registry)
9.drug use (not in the register)
10.persons who are institutionalized by official or judicial order
are placed in an institution
- Claustrophobia
- Metal implants, active medical implants (e.g.
Infusion pump, etc.), or other conditions that preclude an MRI examination
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method - Difference in flow and time-volume responses of the inferior vena cava to LBNP in the supine position between patients with EDS and healthy controls.
- Secondary Outcome Measures
Name Time Method - Difference in flow and volume response of the truncus pulmonalis during supine LBNP between patients with EDS compared with healthy subjects.<br>- Differences in flow and volume response of the ascending aorta during supine LBNP between patients with EDS compared with healthy subjects<br>- Differences in heart size and function between EDS patients and healthy controls;<br>- Difference in plasma volume between EDS patients and healthy controls;<br>- Differences in sympathetic nerve activity as well as release of catecholamines during the tilt table test between EDS patients and healthy controls.<br>- Difference in the extent of fascicle dynamics between EDS patients and healthy controls;<br>