The effect of flavonoids and vitamin C on periodontitis
- Conditions
- Periodontitis - ParodontitisVitamin C - Vitamine CFlavanoids - FlavonoidenQuercetin - Quercetine
- Registration Number
- NL-OMON22290
- Lead Sponsor
- Academic Centre for Dentistry Amsterdam (ACTA)University of Amsterdam (UVA) and Vrije Universiteit (VU) AmsterdamGustav Mahlerlaan 3004, 1081 LA AmsterdamThe Netherlands
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 81
Inclusion Criteria
age: ≥18 years;
- proximal bone loss of ≥ 3mm in 2 non-adjacent teeth;
Exclusion Criteria
- diagnosis of any acute periodontal problem which requires immediate treatment;
- use of antibiotics within the previous 6 months;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary response variable of the present study with respect to the clinical measurements is bleeding on pocket probing (bop).
- Secondary Outcome Measures
Name Time Method With regard to the systemic inflammatory biomarkers HbA1C, hs-CRP, and vitamin C (from venous blood).
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie flavonoid and vitamin C effects on periodontitis inflammation and oxidative stress?
How does vitamin C plus flavonoid supplementation compare to standard periodontal therapies in clinical outcomes for NL-OMON22290?
Which biomarkers correlate with response to flavonoid-vitamin C combinations in periodontitis patients post-treatment?
What adverse events are associated with high-dose vitamin C and flavonoid supplementation in periodontitis management?
How do quercetin and other flavonoids synergize with vitamin C to modulate systemic inflammation in periodontitis trials?