Pain mechanisms and fatigue in rheumatoid arthritis (RA) and healthy volunteers. Can antirheumatic and biological therapy affect pain processing and fatigue in RA? - RA PAIN PROCESSING

Karolinska Institute0 个研究点开始时间: 2008年8月14日最近更新: 2012年3月19日

试验速览

暂无简介。

•Rheumatoid arthritis: Only female patients will be included, this is because it is needed to minimize inter-individual differences in pain perception, known to be significantly dependent on gender (Soetano et al. Are there gender differences in pain perception? J Neurosci Nurse 2006;38:172-176; Garcia et al. Gender differences in pressure pain threshold in a repeated measures assessment. Psychol Health Med 2007;12:567-579). Age 20-50. Fulfilling ACR criteria for RA. The responsible Rheumatologist have found need for antirheumatic treatment with Remicade.
•Healthy controls: Females. Age 20-50.
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range
•F.1.3 Elderly (>=65 years) no
•F.1.3.1 Number of subjects for this age range

•RA: Males (se explanation under E.3). Fulfilling ACR criteria for fibromyalgia. left-handness (for fMRI). Significant heart disease. Current treatment with antidepressive drugs. Contraindications for Remicade.
•Healthy controls: Males. Fulfilling ACR criteria for RA or fibromyalgia. Recurrent pain problems (>40 mm on VAS scale for pain). Left-handness (for fMRI). Significant heart disease. Current treatment with antidepressive drugs. Neurological disease. Diabetes Mellitus.

发起方

Karolinska Institute