NCT05082207已完成不适用
Effect of Ischemic Preconditioning on Dynamic Thiol-disulfide Balance, Randomized Controlled Trial
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- thiol/disulfide homeostasis
研究概览
简要总结
Various strategies have been proposed to prevent or mitigate the effects of ischemia-reperfusion injury following the use of tourniquets in orthopedic surgery cases. One of them is applying "remote ischemic preconditioning." This randomized controlled trial is planned to evaluate the effectiveness of remote ischemic preconditioning in preventing tourniquet-induced ischemia-reperfusion injury in total knee arthroscopy with dynamic thiol-disulfide homeostasis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •ASA I-III patients who will undergo total knee arthroplasty surgery under elective conditions
排除标准
- •emergency operation,
- •Underlying neurological disorder,
- •Underlying peripheral vascular disease,
- •other types of concurrent surgery.
结局指标
主要结局
thiol/disulfide homeostasis
时间窗: 24th hour after surgery
Thiol/disulphide homeostasis will be determined at preoperatively and just before the tourniquet opened and at the 1st, 6th and 24th hours after the tourniquet is opened.
次要结局
未报告次要终点
研究者
Betul Kozanhan
Ass.Prof.
Konya Meram State Hospital
研究点 (2)
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