Ischemic Preconditioning and Thiol-disulfide Balance
Not Applicable
Completed
- Conditions
- Tourniquets
- Interventions
- Other: Remote Ischemic PreconditioningOther: sham group
- Registration Number
- NCT05082207
- Lead Sponsor
- Konya Meram State Hospital
- Brief Summary
Various strategies have been proposed to prevent or mitigate the effects of ischemia-reperfusion injury following the use of tourniquets in orthopedic surgery cases. One of them is applying "remote ischemic preconditioning." This randomized controlled trial is planned to evaluate the effectiveness of remote ischemic preconditioning in preventing tourniquet-induced ischemia-reperfusion injury in total knee arthroscopy with dynamic thiol-disulfide homeostasis.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
- ASA I-III patients who will undergo total knee arthroplasty surgery under elective conditions
Exclusion Criteria
- emergency operation,
- Underlying neurological disorder,
- Underlying peripheral vascular disease,
- other types of concurrent surgery.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Remote Ischaemic preconditioning (RIPC) Remote Ischemic Preconditioning The group underwent Remote Ischemic Preconditioning. Sham Group sham group Sham control group without remote ischemic preconditioning
- Primary Outcome Measures
Name Time Method thiol/disulfide homeostasis 24th hour after surgery Thiol/disulphide homeostasis will be determined at preoperatively and just before the tourniquet opened and at the 1st, 6th and 24th hours after the tourniquet is opened.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Betul Kozanhan
🇹🇷Konya, Turkey