thrombogenicity and platelet reactivity as risk factors for postoperative microemboli signals in patients undergoing carotid endarterectomy
- Conditions
- arteriosclerosisstroke1000796310003216
- Registration Number
- NL-OMON32409
- Lead Sponsor
- Academisch Ziekenhuis Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Withdrawn
- Sex
- Not specified
- Target Recruitment
- 100
patients with an ischemic stroke or TIA (first episode or recurrent disease) AND:
an ipislateral stenosis of the carotid artery for which operation of the carotid artery is indicated.
Patients need to have an adequate transtemporal window for TCD monitoring og the ateria cerebri media
Age > 18 year and < 90years
proven coagulopathies
pregnancy
active infections
chronic inflammatory diseases
anti-phospholipid syndrome
active malignancy
recent cardiovascular intervention (< 3 months)
cardiac arrythmias
postradiation stenosis of the carotid artery
patients with exlusion criteria for MRi can participate in the study, they will not undergo MRI investigations. Exclusion criteria are: feroomagnetic implans, introcular iron splinters, vascular clips and claustrophobia.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The amount (mean and peak) of MES, measurd with TCD, starting from the first<br /><br>postoperative hour, during a period of 3 hours. </p><br>
- Secondary Outcome Measures
Name Time Method <p>a recurrent ipsilateral ischaemic stroke, or death within a period of 1 year<br /><br>starting from the day of the operation</p><br>
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