Comparison of two topical vitamin D analogues in form of ointments in combination with phototherapy in treatment of psoriasis
Not yet recruiting
- Conditions
- Psoriasis vulgaris,
- Registration Number
- CTRI/2022/06/043333
- Lead Sponsor
- Kamal Aggarwal
- Brief Summary
To compare the clinical efficacy and safety of topical calcipotriol ointment with narrow band ultraviolet-B phototherapy versus topical calcitriol ointment and narrow band Ultraviolet-B phototherapy in the treatment of psoriasis.
To compare the safety of the two combinations by assessing the adverse effects.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not Yet Recruiting
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
Patients with stable plaque psoriasis not exceeding 50% of body surface area involvement of age more than 18 years, according to the rule of nine, was included in this study.
Exclusion Criteria
- •Patients of age 18 years and below.
- •Patients who have used systemic antipsoriatic treatment or phototherapy within 2 months prior to the study.
- •Patients having intolerance or previous failure to phototherapy.
- •Patients using phototoxic drugs or drugs influencing psoriasis (lithium, beta blockers etc).
- •Patients with hypersensitivity to calcipotriol or calcitriol.
- •Patients with known hypercalcemia or hypersensitivity to calcipotriol.
- •Patients with a history suggestive of photosensitivity or polymorphic light eruptions.
- •Patients with previous or current carcinoma of the skin or actinic keratosis.
- •Pregnant patients or lactating mothers.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare efficacy between topical calcipotriol and topical calcitriol to compare the difference of calcipotriol and calcitriol over 12 week period
- Secondary Outcome Measures
Name Time Method To compare the safety of the two combinations by assessing the adverse effects. 1 year
Trial Locations
- Locations (1)
Skin OPD Pandit B.D. Sharma PGIMS Rohtak
🇮🇳Rohtak, HARYANA, India
Skin OPD Pandit B.D. Sharma PGIMS Rohtak🇮🇳Rohtak, HARYANA, IndiaDisha ChakrabortyPrincipal investigator9674074135docdishachaks@gmail.com