Comparison of two physiotherapy rehabilitation programmes on the exercise capacity in patients with severe pulmonary hypertensio

Completed

Conditions: Pulmonary hypertension
Circulatory System
Other pulmonary heart diseases

Registration Number: ISRCTN06900747

Lead Sponsor: niversity Hospital Basel (Switzerland)

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 36

Inclusion Criteria

1. Patients with pulmonary hypertension diagnosed by right heart catheterisation (mean pulmonary pressure [PAPm] > 25 mmHg)
2. New York Heart Association (NYHA) III - V
3. Walking distance (6-minutes walk test) > 150 meters
4. Patients with stable conditions on PH-related medication (single, double or triple therapy)
5. In stable condition for at least 3 months

Exclusion Criteria

1. Skeletal or muscular restrictions which make the training impossible
2. New occurrence of syncope
3. Concomitant neurological diseases
4. Patients with neoplastic diseases
5. Mental disability making a proper evaluation of the study impossible
6. Age > 18 years < 85
7. Rapid fatal disease

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in walking distance (6-minutes walk test) after 12 weeks of training and 12 weeks follow up

Secondary Outcome Measures

Name	Time	Method
1. Change in VO2 submax (mobile spiroergometry) after 12 weeks of training and 12 weeks follow up<br>2. Change in scores for quality of life (SF-36 questionnaire) after 12 weeks of training and 12 weeks follow up<br>3. Change in scores (MRC-Dyspnoea scale) after 12 weeks of training and 12 weeks follow up<br>4. Change in daily activity measured with an accelerometer AiperMotion 320 after 12 weeks of training and 12 weeks follow up