Effect of Carica papaya leaf extract on Dengue Feve

Not Applicable

Conditions: Dengue fever

Registration Number: SLCTR/2013/005

Lead Sponsor: one

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete: follow up complete

Sex: Not specified

Target Recruitment: Not specified

Inclusion Criteria

Male and female patients admitted to the university medical unit at Colombo South Teaching Hospital fulfilling ALL the following criteria will be included in this study. (1) >18 and <60 years of age (2) Acute onset of fever (3) Platelet count <150,000 per cu.mm and / or Hct elevated by 5% and / or white cell count <5000/cu.mm. (4) Dengue IgM positive after 7 days of illness

Exclusion Criteria

(1) History of allergy to papaya (2)Pregnancy (3)Patients who have already taken papaya juice extracts before admitting to hospital (4) Patients with previously diagnosed abnormal clotting profile as per past history and medical records (5) Patients suffering from any other illnesses which will influence the course of dengue fever. (6) Patients suffering from any other illnesses or on drugs which will influence the bone marrow function or haemopoitic system. (7) Dengue patients who are being treated with blood products. (8) Patients with severe hemorrhagic dengue (9) Dengue IgM negative after 7 days of the illness

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
White blood cell count (WBC) / Differential counts <br> [At recruitment and daily until discharge ]<br>The platelet count <br> [At recruitment and daily until discharge ]<br>Haematocrit [At recruitment and daily until discharge ]<br>The prothrombin time (PT) [At recruitment and daily until discharge ]<br> Alanine aminotransferase (ALT) [At recruitment and daily until discharge ]<br>Presence of pleural effusion [At recruitment and daily until discharge ]<br>Serum cholesterol [At recruitment and daily until discharge ]<br> CD 4 counts [Before ingestion of first dose and after completing 3 days of treatment]<br>

Secondary Outcome Measures