Antisocial developmental Trajectories

Recruiting

Conditions: antisocial personality disorder - antisocial behavior
10034726

Registration Number: NL-OMON50264

Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 190

Inclusion Criteria

Subject is in very young offender-cohort.
Or control subjects; subjects with the same age and educational level as
participants from the very young offender cohort (19-25 years)

Exclusion Criteria

Intraocular shreads of metal. Cardiac pacemaker, metal arterial clips, cochlear
implant, implanted heart-valves, other implants or metal objects in the body
(e.g. non-removable body piercings) not compatible with magnetic fields . Use
of medication effecting brain functioning, except for short-acting medication
that can be stopped for two days during the day of scanning and the day before.
In the latter case, the physician of the participant will be consulted.
Pregnancy.

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Differential BOLD-response (i.e. blood flow to brain areas thought to reflect<br /><br>activation in these areas) in relevant neuronal networks during fear<br /><br>conditioning as well as during reward/punishment anticipation and outcome.<br /><br><br /><br>Amendement genetica: Genetic variation (Single Nucleotide Polymorphisms,<br /><br>SNPs), gene expression data.<br /><br><br /><br>' Amendement Wave 5': (1) Difierenttal BOLD-æsponse in relevant neuronal<br /><br>networks including self-concept evaluation, vicarious reward leaming and<br /><br>impulse control, {2) developmental changes in brain structure and (3) stability<br /><br>of antísocial behaviour over time.*<br /><br><br /><br>'EEG / Justice amendment': (addition to wave 5): EEG recording, criminal<br /><br>recidivism based on official registration systems [police / justice] and cyber<br /><br>crime.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Fear conditioning (CS-US contingency in terms of skin conductance levels,<br /><br>arousal and emotional valence), reward- and punishment-anticipation,<br /><br>self-reported criminal recidivism.<br /><br><br /><br>Amendement genetica:networks of functionally related genes, epigenetic<br /><br>changes.<br /><br><br /><br>'Amendement Wave 5': behavior on affective control, social fear learing and<br /><br>moral learning; self-reported criminal recidivism, testosterone.<br /><br><br /><br>'Amendement EEG/Justice': -</p><br>