Plasma Rich in Growth Factors in Post-extraction Sockets

Not Applicable

Active, not recruiting

• Conditions: Tooth Extraction; Dental Implants
• Interventions: Device: ABB; Device: PRGF

• Registration Number: NCT03943680
• Lead Sponsor: Universidad de Granada

Brief Summary

The purpose of this study is to compare the clinical success, radiographical volume maintenance and histological bone regeneration after using either a bovine bone xenograft or an autogenous platelet rich plasma enrich in growth factors, known as Endoret®-PRGF®.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-03-04
• Study First Submitted: 2019-05-07
• Study First Submitted QC: 2019-05-07
• Study First Posted: 2019-05-09
• Primary Completion: 2024-11-18
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-25
• Last Update Posted: 2025-03-30
• Study Completion: 2025-07

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Upper or lower premolar or molar tooth in need of extraction and later restoration by dental implant.
• Adjacent and opposing natural teeth present and healthy.
• At least 3 mm from the tip of the dental root to the maxillary sinus or the inferior alveolar canal.

Exclusion Criteria

• Active local infection.
• Uncontrolled diabetes mellitus.
• Long term (>10 years) use of oral bisphosphonates.
• Use of intravenous bisphosphonates.
• Recent use (<3 months) of antibiotics, antiinflammatories or analgesics drugs.
• Pregnancy.
• Smokers of more than 10 cigarettes per day.
• Any oral pathology that needs to be treated before tooth extraction, particularly the presence of more than 25% of sites with bleeding on probing.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
ABB	ABB	Post-extraction socket grafted with anorganic bovine bone (ABB)
PRGF	PRGF	Post-extraction socket grafted with PRGF-Endoret

Primary Outcome Measures

Name	Time	Method
Alveolar bone change in Cone Beam Computerized Tomography	Baseline and 4 months	Volumetric change in the alveolar bone from immediately after tooth extraction to immediately before implant placement (4 months after the extraction and grafting of the socket)

Trial Locations

Locations (1)

Facultad de Odontología; 🇪🇸 Granada, Spain