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Clinical Trials/NCT05426408
NCT05426408
Recruiting
Not Applicable

Stockholm Myocardial Infarction with Nonobstructive Coronaries Study 3 - Pilot Study of Prevalence of Coronary Microvascular Dysfunction in Myocardial Infarction with Nonobstructive Coronary Arteries

Karolinska Institutet1 site in 1 country85 target enrollmentStarted: November 1, 2022Last updated:
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Overview

Phase
Not Applicable
Status
Recruiting
Enrollment
85
Locations
1
Primary Endpoint
Diagnostic yield
OverviewStudy DesignEligibility CriteriaOutcomesInvestigatorsSitesRecords & IdentifiersSimilar Trials

Overview

Brief Summary

The present pilot study will investigate the prevalence of CMD in an unselected cohort of patients with the working diagnosis MINOCA and to study if the diagnostic yield can be improved by adding adenosine to the CMR investigation. Patient will be their own controls.

Study Design

Study Type
Interventional
Allocation
Na
Intervention Model
Single Group
Primary Purpose
Diagnostic
Masking
None

Masking Description

The investigators who will perform the evaluation of the CMR investigations will be blinded to all clinical data.

Eligibility Criteria

Ages
35 Years to 79 Years (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • •a suspected diagnosis of MINOCA or takotsubo syndrome with coronary angiography without diameter stenosis ≥50%
  • •age 35-80 years
  • •reading and writing proficiency in Swedish

Exclusion Criteria

  • •Claustrofobia
  • •Arrythmia and/or pacemaker (atrial fibrillation and AV-block I- III)
  • •Asthma or severe chronic obstructive lung disease
  • •eGFR \< 30 ml/min
  • •spontaneous coronary artery dissection
  • •acute pulmonary embolism
  • •acute myocardial infarction type 2
  • •cardiomyopathy other than takotsubo syndrome
  • •a previous myocardial infarction due to CAD

Outcomes

Primary Outcomes

Diagnostic yield

Time Frame: Through investigation completion, usually 2 hours

To increase the diagnostic yield of CMR imaging in MINOCA as a working diagnosis

Secondary Outcomes

  • Prevalence of CMD in different final MINOCA diagnoses(Through investigation completion, usually 2 hours)
  • Prevalence of CMD in MINOCA(Through investigation completion, usually 2 hours)
  • Angina pectoris(3 Months)

Investigators

Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Per Tornvall

Professor

Karolinska Institutet

Study Sites (1)

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