Effect of nanofat injection alone and combined with SVF, PRP and ND-YAG laser on treatment of periorbital dark circles and rejuvenatio

Phase 1

• Conditions: ?Darkening under the eye.; disorder of pigmentation, unspecified; L81.9

• Registration Number: IRCT20200127046282N21
• Lead Sponsor: Tehran University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 7 February 2023

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Under eye wrinkles, dark circles and need for rejuvenation based on dermatologist's diagnosis
No medical treatment for under eye's dark circles, wrinkles and rejuvenation in recent 2 months
Patients' Informed consent
Ages under 50 and over 18 years

Exclusion Criteria

Skin lesions and diseases such as skin cancer
Wart
Skin infection
Collagen and vascular diseases
Pregnancy and lactation
Taking steroids or anti-immune drugs

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Darkness under the eyes. Timepoint: prior to treatment, three and six months after the last treatment session. Method of measurement: VisioFace device.;Under eye rejuvenation. Timepoint: prior to treatment, three and six months after the last treatment session. Method of measurement: Visioface.;Safety of treatment method. Timepoint: in the Injection session and one week after each session. Method of measurement: Questionnaire and clinical observation.

Secondary Outcome Measures

Name	Time	Method
Pain Intensity. Timepoint: Injection session. Method of measurement: Questionnaire (scoring from 1 to 10) and visual pain questionnaire.;Patient satisfaction. Timepoint: prior to treatment, three months and six months after the last treatment session. Method of measurement: Standard questionnaires visual analogue scale (VAS).;Inflammation. Timepoint: 1-5 hours after injection. Method of measurement: In this study,?the inflammation rate around the eyes (with scores of 0 and 1), will be performed by a physician.