A Clinical trial to study the effect of steroids in patients with jaundice
Phase 3
- Conditions
- Health Condition 1: null- ACUTE CHOLESTATIC VIRAL HEPATITIS A
- Registration Number
- CTRI/2011/10/002083
- Lead Sponsor
- CALICUT MEDICAL COLLEGE
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 32
Inclusion Criteria
PATIENTS WITH A DIAGNOSIS OF ACUTE VIRAL HEPATITIS A
SERUM BILIRUBIN MORE THAN 10MG/DL
SEVERE CHOLESTATIC SYMPTOMS GRADE 3 OR 4 PRURITIS
Exclusion Criteria
PATIENTS POSITIVE FOR HEPATITIS B AND C ,
PREGNANT AND LACTATING FEMALES ,
PATIENTS SUFFERING FROM MAJOR ILLNESS WILL BE EXCLUDED
PATIENT WITH HISTORY OF HEAVY ALCOHOL MORE THAN 40MG/DAY IN THE RECENT PAST,
THOSE SUFFERING FROM DIABETES , HYPERTENSION AND HAVING FEATURES OF LIVER FAILURE WILL BE EXCLUDED.
PATIENTS WITH ATOPIC DERMATITIS, SCABIES AND PRURITIS DUE TO OTHER ETIOLOGIES WILL ALSO BE EXCLUDED
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The purpose of this study is to asses the effect of short course steroid treatment in acute <br/ ><br>cholestatic viral hepatitis A,and whether steroid use is associated with improvement in cholestatic symptoms and pruritis .Timepoint: serial monitoring of clinical and laboratory parameters twice in the first 10 days and then weekly till 4 weeks and monthly for 6 months <br/ ><br>
- Secondary Outcome Measures
Name Time Method SECONDARY OUTCOME IN THE FORM OF SIDE EFFECTS IF ANY WHEN USING SHORT TERM STEROIDS CAN BE OBSERVED.Timepoint: Study intend to asses clinical and laboratory improvement in patients at the end of 1st week, 2 nd week and 3 rd week.