Comparison of the Impacts of Pea, Lentil, and Oat Flour Particle Size on Postprandial Glycemic Response and Appetite in Healthy Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- Change in postprandial glycemic response
研究概览
简要总结
The study looks at the comparative effects of food products made with pea, lentil, and oat flour of various particle sizes on postprandial glycemic response, appetite and food intake, and amino acid release in healthy adults.
详细描述
A total of 60 participants (30 males, 30 females) will take part in this study at the University of Toronto. Twenty participants will be recruited to each one of three trials (pea, lentil or oat) and will attend 4 study sessions where they will consume crackers/porridge made with pea, lentil, oat, or wheat flours of different particle sizes. Questionnaires will be filled out to assess their recent food intake, physical activity, sleep quality, stress level, appetite, physical comfort, and energy/fatigue level, as well as tastefulness of the food. Blood samples will be collected at fasting and at various time points over a 2 hour period after eating to measure blood glucose, insulin, and amino acid concentrations. Before leaving, participants will receive an all-you-can-eat pizza meal to assess their food intake.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18-45 years of age
- •BMI 18.5-29.9 kg/m2
- •Willing to maintain habitual diet, physical activity pattern, and body weight throughout the trial.
- •Willing to maintain current dietary supplement use throughout the trial.
- •Willing to abstain from alcohol consumption for 24h prior to all test visits.
- •Willing to avoid vigorous physical activity for 24h prior to all test visits.
- •Understanding the study procedure and willing to provide informed consent to participate in the study and authorization to release relevant protected health information to the study investigator.
排除标准
- •Thyroid problems
- •Previous history of cardiovascular disease, diabetes, liver or kidney disease, inflammatory bowel disease, celiac disease, short bowel syndrome, a malabsorptive syndrome, pancreatitis, gallbladder or biliary disease.
- •Presence of a gastrointestinal disorder or surgeries within the past year.
- •Known to be pregnant or lactating.
- •Unwillingness or inability to comply with the experimental procedures and to follow our safety guidelines.
- •Allergies to peanuts and nuts.
- •Known intolerances, sensitivity or allergy to any ingredients in the study products: pea flour, lentil flour, oat flour and whole wheat flour.
- •Regular breakfast skipping (consumes breakfast less than 5 days a week)
- •Extreme dietary habits (i.e Atkins diet, very high protein diets, etc.) or restrained eaters, identified by a score of ≥ 11 on the Eating Habits Questionnaire
- •Uncontrolled hypertension (systolic blood pressure > 140 mm Hg or diastolic blood pressure > 90 mm Hg) as defined by the average blood pressure measured at screening.
- •Weight gain or loss of at least 10lbs in previous three months.
- •Excessive alcohol intake (more than 2 drinks per day or more than 9 drinks per week).
- •Consuming prescription or non-prescription drug, herbal or nutritional supplements known to affect blood glucose or that could affect the outcome of the study as per investigator's judgment.
结局指标
主要结局
Change in postprandial glycemic response
时间窗: Blood glucose will be measured at baseline and at 15, 30, 45, 60, 90, 120, and 140 minutes after treatment consumption. Insulin will be measured at baseline and every half an hour after treatment consumption over 2 hours.
Blood collection via finger prick to analyze blood glucose (glucometer reading) and serum insulin concentration (μIU/mL).
次要结局
- Food intake(2 hours after treatment consumption.)
- Subjective appetite(At baseline and at 15, 30, 45, 60, 90, 120, and 140 minutes after treatment consumption.)
- Physical comfort(At baseline and at 15, 30, 45, 60, 90, 120, and 140 minutes after treatment consumption.)
- Protein quality(At baseline and every half hour after treatment consumption over a period of 2 hours, and after pizza meal.)
- Treatment palatability(Immediately after treatment consumption.)
- Energy & fatigue(At baseline and at 15, 30, 45, 60, 90, 120, and 140 minutes after treatment consumption.)
研究者
G. Harvey Anderson
Professor
University of Toronto