ung function and exercise capacity in late preterms
Withdrawn
- Conditions
- 10010613preterm infants
- Registration Number
- NL-OMON35437
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Withdrawn
- Sex
- Not specified
- Target Recruitment
- 119
Inclusion Criteria
Late Preterms: 40 children of the 'Pinkeltje' cohort with pregnancy duration 32-36 weeks.
Term born children: 40 children of the 'Pinkeltje' cohort with pregnancy duration 38-41 weeks.
All living in Friesland, Groningen or Drenthe.
All children from the 'Pinkeltje' cohort who are hospitalised because of RSV (n=39)
Exclusion Criteria
Children with major congenital abnormalities
Children who are not able to perform a lung function test and/or an exercise test
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Spirometry: FEV1,<br /><br>Total lung capacity: RV/%TLC,<br /><br>diffusion capacity: Dlco,<br /><br>nitrogen monoxide: FeNO<br /><br>provocation test: PD20 metacholine<br /><br>exercise test: VO2 max. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Spirometry: FVC, FEV1/FVC, FEF25, FEF50, FEF75, PEF<br /><br>Total lung capacity: TLC, TGV, RV , Raw, sGaw<br /><br>diffusion capacity: DLco va, Kco<br /><br>resistance measure: Rrs6<br /><br>exercise test: Heart rate max, heart rate reserve, breathing frequency, maximal<br /><br>load, VO2 rest, breathing frequency, VT , VTmax, VEmax, ventilatory reserve,<br /><br>VO2 at AT, VO2max, AT, AT/ VO2, ΔVO2/ ΔWR, respiratory exchange ration, borg<br /><br>score<br /><br>-for comparison of the RSV admitted children with the non-RSV-admitted children<br /><br>the same studyparameters will be used.<br /><br>-Sensibility, specifity and ROC-curves will be calculated to determine the most<br /><br>discriminative test </p><br>