Efficacy of Lactoferrin as Adjunct Therapy for Pneumonia in Children and Adolescents
试验速览
- 阶段
- 不适用
- 入组人数
- 72
- 主要终点
- Survival rate.
研究概览
简要总结
Pneumonia is defind as the inflammation of lung tissue caused by an infectious agent that results in acute respiratory signs and symptoms. Community acquired pneumonia (CAP) is a major cause of morbidity and increased health care costs. In developing nations, pneumonia remains a significant cause of mortality in children.
Pneumonia occurs in 30 to 45 of every 1,000 children under 5 years of age; it is less common in 5- to 9-year olds (16 to 22/1,000) and in older children (7 to 16/1,000).
Streptococcus pneumoniae is the primary bacterial cause of pneumonia in infants and children. Viral etiologies become less prevalent and mycoplasmal and chlamydial infections become more prevalent with increasing age
详细描述
Lactoferrin (LF) is iron-binding glycoprotein of the transferrin family that is expressed and secreted by glandular cells and is found in most body fluids . It appears at especially high concentrations in mammalian milk and was first identified in bovine milk , and was subsequently isolated from human milk.
LFs bacteriostatic function is due to its ability to take up the Fe3+ ion, limiting use of this nutrient by bacteria at the infection site and inhibiting the growth of these microorganisms as well as the expression of their virulence factors .
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 1 Month 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Pneumonia patients
- •from the age of one month to the age of 18 years .
排除标准
- •Neonates and any children with :
- •immune deficiency
- •congenital heart disease
- •neuromascular disorder
- •genetic syndromes
研究组 & 干预措施
Patients with pneumonia who receive only treatment for pneumonia
They receive only treatment for pneumonia
干预措施: Pneumonia treatment (Drug)
pneumonia patients receive treatment for pneumonia and lactoferrin
They receive treatment for pneumonia and lactoferrin
干预措施: Lactoferrin (Drug)
pneumonia patients receive treatment for pneumonia and lactoferrin
They receive treatment for pneumonia and lactoferrin
干预措施: Pneumonia treatment (Drug)
结局指标
主要结局
Survival rate.
时间窗: Up to 8 weeks
Comparing the influence of the intervention on the Survival rate.
次要结局
- Mean change in the disease severity (clinical assessment)(Up to 4 weeks)
研究者
Omima mahran hussein
Principal investigator
Assiut University