Assessment of different doses of tomato intake on blood pressure and endothelial function in patients at high vascular risk: nutrigenomics effect on different phenotypes of risk

Completed

• Conditions: Arteriosclerosis and its risk factors; Circulatory System

• Registration Number: ISRCTN99660610
• Lead Sponsor: Spanish Ministry of Science and Innovation (Ministerio de Ciencia e Innovación, MICINN) (Spain)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2013-08-02
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 72

Inclusion Criteria

Acute study.
Healthy volunteers, body mass index between 18.5 and 24 Kg/m2, and no history of cardiovascular disease or haemostatic abnormalities.

Chronic study.
Hypertensive patients, male and female, between 55 and 80 years without documented cardiovascular disease (ischemic heart disease -angina pectoris or recent myocardial infarction or old-, stroke, or peripheral vascular disease), but who had two or more of the following cardiovascular risk factors:
1. Smoking,
2. Diabetes mellitus,
3. LDL-cholesterol > 160 mg/dl.
4. HDL-cholesterol < 40 mg/dl.
5. Overweight or obesity (Body mass index > 25 kg/m2).
6. Family history of premature ischemic heart disease.

Exclusion Criteria

Acute study.
Previous history of cardiovascular disease (ischemic heart disease - angina or recent or old myocardial infarction, cerebral vascular accident, or peripheral vascular disease), homeostatic disorders, any several chronic diseases, hypertension or dislipemia, smokers, alcoholism or other addiction, or allergy or intolerance to tomatoes .

Chronic study.
Healthy adults (males and females). Participants with previous history of cardiovascular disease, any severe chronic illness, alcoholism or other addiction, or allergy or intolerance to tomatoes.

Study & Design

• Study Type: Interventional
• Study Design: Not specified