Comparison of effect of intravenous Dexmedetomidine, Esmolol and combination of Esmolol and Dexmedetomidine for attenuation of hemodynamic stress response to laryngoscopy and endotracheal intubation.

Patients posted for elective surgeries under general anaesthesia will be assessed according to eligibility criteria. A total of 63 (21 in each group) patients will be selected. The procedure will be explained to the patients and informed, written consent will be obtained in a language that is understood by the patient. All standard monitors will be attached and baseline heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP) will be recorded. Intravenous access will be established and a venous sample for baseline serum cortisol and blood sugar levels will be taken. According to randomization into 3 groups, patients will be administered intravenous Dexmedetomidine (1 mcg/kg) in group 1, Esmolol (1 mg/ kg) in group 2 and combination of Esmolol (0.5 mg/kg) and Dexmedetomidine (0.5 mcg/kg) in group 3. Induction will be done followed by Laryngoscopy and Endotracheal Intubation. Hemodynamic monitoring will be done at 1, 3 and 5 minutes post-intubation and blood sampling for biochemical markers will be done at 5 minutes post-intubation. Statistical methods will be used to analyse collected data.