Clinical Study of Fecal Microbiota Transplantation in the Treatment of Antibiotic-associated Diarrhea
Not Applicable
Completed
- Conditions
- Antibiotic-associated DiarrheaFecal Microbiota Transplantation
- Interventions
- Procedure: Fecal Microbiota Transplantation
- Registration Number
- NCT05990972
- Lead Sponsor
- Shanghai 10th People's Hospital
- Brief Summary
Antibiotic-associated diarrhea (AAD) refers to the occurrence of other unexplained diarrhea symptoms after the use of antibiotics, often combined with abdominal pain, bloating and bloody stool. Fecal Microbiota Transplantation (FMT) is a therapeutic method to transplant the microbiota from the feces of healthy people into the intestinal tract of patients. To explore the overall efficacy and safety of FMT in the treatment of AAD.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 25
Inclusion Criteria
- occurrence of antibiotic-associated diarrhoea; no response to standard therapy; agree to receive FMT and sign informed consent; willingness to provide stool samples.
Exclusion Criteria
- non-antibiotic-associated diarrhea; did not accept FMT or did not sign informed consent; unwillingness to provide stool samples.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description FMT group Fecal Microbiota Transplantation -
- Primary Outcome Measures
Name Time Method Changes in defecation frequency after FMT. Baseline and three months after treatment Changes in gut microbiota after FMT. Baseline and three months after treatment.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Intestinal Microenvironment Treatment Center of General Surgery, Shanghai Tenth People's Hospital, Tenth People's Hospital of Tongji University
🇨🇳Shanghai, China