The effect of metformine on the uteroplacental circulation in comparison with Aspirin in pregnant women with poly cystic ovary syndrome

Phase 3

• Conditions: teroplcental circulation and complication of pregnancy.; Pcos (poly cystic ovary syndrome)

• Registration Number: IRCT138812123485N1
• Lead Sponsor: Tehran University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: Female
• Target Recruitment: 105

Inclusion Criteria

PCOS diagnosis before pregnancy was based on the presence of poly cystic ovaries verified by ultrasonography and oligomenorea (length of menstrual cycle more than 35 days or hirsutism, gestational age 5-12 weeks, single live fetus, pregnant women between 18-40years and
Exclusion criteria: Inability to follow up

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
teroplcental circulation. Timepoint: At 12th week of gestational age (before intervention) and 8 weeks after intervention. Method of measurement: Uterine Artery Doppler Ultrasound.

Secondary Outcome Measures

Name	Time	Method
Preterm labour. Timepoint: After Delivery. Method of measurement: Termination of pregnancy before 37th gestational age.;Preeclampsia. Timepoint: Monthly routine control of pregnancy. Method of measurement: Evaluation of BP and urine protein exam.;Rate of Gestational Diabet. Timepoint: at 24-28 weeks of pregnancy or 12-16 weeks after intervention. Method of measurement: GTT.;Rate of IUGR. Timepoint: After Delivery. Method of measurement: weight below the 10th percentile for gestational age after Delivery.