Correlation Between the Changes of Retinal Structure and Function and Ischemic Stroke

Recruiting

• Conditions: Ischemic Stroke

• Registration Number: NCT05281887
• Lead Sponsor: Guangdong Provincial People's Hospital

Brief Summary

Ischemic stroke is the most common type of stroke, accounting for 60%-80% of all types of strokes, and is one of the leading global causes of death and severe disability. In the risk factors of stroke, carotid atherosclerosis have higher incidence.As the only visible microvessels in vivo, retinal can provides an accurate window into cerebrovascular and systemic vascular conditions. Optical coherence tomography angiography (OCTA) and electroretinogram (ERG) can be used to quantitatively analyze the retinal structure and function in patients with ischemic stroke, and find out the valuable parameters. Electroencephalogram(EEG) can collect the electrical activity of cerebral cortex in patients with ischemic stroke and find the correlation between EEG and ERG. Finally, it is of great significance to establish a non-invasive, more objective, convenient and safe risk prediction model for stroke in combination with carotid atherosclerosis, retinal structural and functional parameters and EEG.

Detailed Description

Firstly, this study will cross sectional analyze the retinal structure and function of patients with ischemic stroke to find the closely related parameters. Secondly, based on the results of cross section analysis, a cohort study will be established to build a risk prediction model for stroke combining carotid atherosclerosis, retinal structure and function parameters and EEG.

Study Timeline

• Status Verified: 2021-12
• Study Start: 2021-12-01
• Study First Submitted: 2022-01-05
• Study First Submitted QC: 2022-03-15
• Study First Posted: 2022-03-16
• Last Update Submitted: 2022-08-08
• Last Update Posted: 2022-08-09
• Primary Completion: 2022-12-31
• Study Completion: 2032-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• Patients with ischemic stroke

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Exclusion Criteria

• Refractive interstitial turbidity affect the examination results
• Any retinal diseases
• Other causes of ischemic stroke (cardiogenic embolism, dissection aneurysm, hemagglutination disorder, polycythemia, vasculitis, vascular malformation, etc.)
• Fails to complete an ophthalmic examination or the follow-up

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Optical coherence tomography angiography (OCTA)	1year	Quantitatively analyzing the retinal microcirculation and structure in patients with ischemic stroke by using OCTA.
Electroretinogram (ERG)	1year	The amplitude(μV) and implicit time(ms) of a-wave, b-wave and oscillatory potentials in dark-adapted and light-adapted.

Trial Locations

Locations (1)

Guangdong Provincial People's Hospital; 🇨🇳 Guangzhou, Guangdong, China