Prevalence of gastroesophageal reflux evaluated by upper gastrointestinal tract examination in ataff health check, and its associations with metabolic syndrome.

Not Applicable

• Conditions: Gastroesophageal reflux disease

• Registration Number: JPRN-UMIN000000616
• Lead Sponsor: Division of Gastroenterology, Department of Internal Medicine, Keio University School of Medicine

Brief Summary

Two hundred and eighty-three subjects (243 men and 40 women; mean age 49.8 +/- 6.9 years) with no radiographic evidence of erosive esophagitis were enrolled. The severity of GER was worse among men than among women, whereas the severity of reflux symptoms was worse among women. The severity of GER was associated with age and serum triglyceride levels in men, and with the serum low-density lipoprotein cholesterol levels in women. The severity of reflux symptoms, however, was not associated with metabolic parameters. There were more women than men with reflux symptoms but without GER ('presumed' functional heartburn group), compared with subjects with neither GER nor reflux symptoms. In men, the presence of both reflux symptoms and GER ('presumed' NERD group) was associated with the serum triglyceride levels. CONCLUSIONS & INFERENCES: While NERD is associated with serum lipid levels, functional heartburn is not. The prevalence of GER was greater among men; conversely, the prevalence of functional heartburn was greater among women.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2007-08-01
• Study Start: 2007-09-01
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 500

Inclusion Criteria

Not provided

Exclusion Criteria

Indivisuals who have any disease such as aliment disease or medical treatment were excluded.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
(1) Prevalence of gastroesophageal reflux disease in stuff members undergoing upper gastro intestinal X-ray examination in health check. (2) Relationship between severity of gastroesophageal reflux and metabolic marker.