Ultrasound Perfusion Imaging After Aneurysmal Subarachnoid Hemorrhage
试验速览
- 阶段
- 不适用
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Change of perfusion
研究概览
简要总结
The purpose of this study is to examine wether delayed cerebral ischemia can be predicted by ultrasound brain perfusion imaging in patients with aneurysmal subarachnoid hemorrhage (SAH).
详细描述
The delayed cerebral ischemia is a main complication in patient with aneurysmal subarachnoid hemorrhage which causes neurological deficit. So far there is no reliable diagnostic tool to predict the appearance of cerebral ischemia.
The causal correlation between presence of cerebral vasospasm measured daily by transcranial Doppler sonography (TCD) and occurrence of cerebral ischemia detected by cranial computed tomography scan (CCT) is not finally verified.
First studies demonstrated that ultrasound perfusion imaging (UPI) allows the detection of perfusion deficits in middle cerebral artery infarction.
The purpose of our study is to evaluate the diagnostic and prognostic value of UPI to predict delayed cerebral ischemia. In our trial we compare parameters of UPI (b= rise rate, A= plateau of acoustic intensity) in patients with aneurysmal subarachnoid hemorrhage with results of follow-up cranial computed tomography scans (CCT), TCD results and clinical outcome.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Aneurysmal subarachnoid hemorrhage, Hunt and Hess 0-5
- •Informed consent
- •Sufficient transtemporal acoustic window
- •First examination within 48h after subarachnoid hemorrhage
- •Minimum Age 18 years
排除标准
- •Contraindication against computed tomographic scan
- •Incompatibility against SonoVue™
- •Acute respiratory distress syndrome
- •Uncontrollable hypertensive crisis
- •Severe pulmonary disease(pulmonary hypertension > 90 mmHg)
- •acute severe cardiac insufficiency (New York Heart Association IV)
- •known right-left-shunt
- •pregnancy and breastfeeding
- •Substance dependence
结局指标
主要结局
Change of perfusion
时间窗: Baseline, Day 5
Detection of hypoperfusion (defined by 50% or more reduction in beta-value of comparing day 1. with day 5.) in one or more of four regions in one or both hemispheres before the detection of delayed ischemia after SAH in CCT.
次要结局
- Change of Perfusion(Baseline, Day 5)
- Correlation between perfusion parameters, clinical course and flow velocities(Day 1 to 90)
研究者
Gunter Seidel, MD
MD, Professor of Neurology
Asklepios Kliniken Hamburg GmbH