NCT07027007尚未招募不适用
Prospective Observational Analysis of Circulating Endocan Levels in Patients Presenting With Acute Diverticulitis
IRCCS Ospedale San Raffaele1 个研究点 分布在 1 个国家目标入组 60 人开始时间: 2025年9月30日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Endocan serum level at admission
研究概览
简要总结
Quantify the level of endocan in blood samples collected from patients with acute diverticulitis in the emergency department. Determine if endocan levels are correlated with the severity of diverticulitis according to the WSES classification. Assess whether patients requiring emergency surgical intervention have higher endocan values compared to others.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who have signed informed consent
- •Patients who are affected by acute diverticulitis after clinical evaluation and imaging (i.e. u.s. or CeCT)
排除标准
- •Immunosuppressed patients
- •Patients suffering chronic inflammatory diseases
- •Patients with concomitant malignancy, cardiac, renal and haepatic failure
- •History of major vascular surgery (aneurysmectomy)
- •Pregnant women
- •Patients participating in other studies that may interfere with the outcome of the intervention.
结局指标
主要结局
Endocan serum level at admission
时间窗: The serum of the patients enrolled inthe study will be collected within two hours from emergency room registation and tested for ENDOCAN
To evaluate the correlation between blood concentration of endocan and severity of diverticulitis
次要结局
- Predictive value of endocan in determining which patients need emergency surgery(Patients will undergo diverticulitis evaluations (per WSES criteria) within 3 hours of Emergency room admission and study enrollment)
- Prognostic value of endocan in determining the risk of recurrent diveritculitis(From discharge after definitive tretament till 12 months follow-up)
研究者
Luca Ghirardelli
MD
IRCCS Ospedale San Raffaele
研究点 (1)
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