临床试验/NCT03592212

NCT03592212进行中（未招募）不适用

Phosphodiesterase 4 Gene Variant and Salbutamol Response in Persistent Childhood Asthma

Assistance Publique - Hôpitaux de Paris2 个研究点分布在 1 个国家目标入组 99 人开始时间: 2018年11月25日最近更新: 2022年11月1日

适应症

试验速览

阶段: 不适用
状态: 进行中（未招募）
发起方: Assistance Publique - Hôpitaux de Paris
入组人数: 99
试验地点: 2
主要终点: pre- and post-bronchodilator VEMS value

研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

This study is designed to investigate whether the Phosphodiesterase 4 gene variability could be implicated in the salbutamol responsiveness in asthmatic children.

详细描述

Patients from 6 to 18 years old with asthma and receiving a treatment by salbutamol according to the usual care will be recruited. Saliva from patients will be collected using Oragen®.DNA OG-575 kit.

研究设计

研究类型: Observational
观察模型: Case Only
时间视角: Other

入排标准

年龄范围: 6 Years 至 18 Years（Child, Adult）
性别: All
接受健康志愿者: 否

入选标准

•Children 6-18 years
•Asthma: confirmed asthma symptoms (wheeze, cough, dyspnea, chest tightness) and evidence for variable airflow limitation (≥ 12% increase in post bronchodilator FEV1, or ≥ 20% decrease in FEV1 post methacholine)
•Spirometry prescribed for follow-up
•Airflow limitation: FEV1<80% and/or FEV1/FVC <80 pre-bronchodilator

排除标准

•no exclusion criteria

结局指标

主要结局

pre- and post-bronchodilator VEMS value

时间窗: Day 0

comparison of acute response to salbutamol calculated as the percentage difference between the pre- and post-bronchodilator VEMS value (BDR = 100 x \[post-VEMS - pre-VEMS\]/pre-VEMS) according to the genotype of the rs1504982

次要结局

Screening other SNPs (other genes than PDE4) associated with the response to salbutamol in childhood asthma using SNP tags(Day 0)
Locating other regions of the PDE4 gene that may be associated with the response to salbutamol by gene mapping (using SNP tags)(Day 0)

研究者

发起方

Assistance Publique - Hôpitaux de Paris

申办方类型

Other

责任方

Sponsor

研究点 (2)

Loading locations...

相似试验

Unknown

4 期

Study of Comparing the Different Effect of DPP-4 Inhibitors and Sulfonylurea by Using "Biphase-Hyperglycemic Clamp"Type 2 Diabetes

NCT01660386Shanghai Jiao Tong University School of Medicine12

已完成

不适用

To investigate DPP-4 inhibitors type dependent effects on antifibrotic miRNA and biomarkers.

JPRN-UMIN000019273Kanazawa Medical University60

已完成

4 期

PDE-4 Inhibitor Roflumilast and Polycystic Ovary SyndromePCOSObesity

NCT02037672University Medical Centre Ljubljana36

已完成

4 期

Comparing the Renal Effect of Dipeptidyl-peptidase 4 Inhibitors and SulfonylureasProteinuriaType 2 Diabetes Mellitus

NCT03983551Changhua Christian Hospital101

Unknown

4 期

Study on Exploring the Effect of DPP-4 Inhibitors on β-cell Function by Using the Two-step Hyperglycemic ClampType 2 Diabetes

NCT02386943Shanghai Jiao Tong University School of Medicine12