Mapping of the supplementary motor area in patients with brain tumors using repetitive navigated transcranial magnetic stimulatio
Not Applicable
Recruiting
- Conditions
- C71Malignant neoplasm of brain
- Registration Number
- DRKS00024065
- Lead Sponsor
- Klinik für Neurochirurgie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 105
Inclusion Criteria
Patients: Suspected tumor after cranial imaging; localisation within supplementary motor area; age > 18 years; written informed consent
Healthy subjects: age > 18 years; written informed consent
Exclusion Criteria
Patients: Contraindications for receiving an MRI; contraindications for receiving a TMS measurement; more than one seizure per week; missing consent to participate in this study
Healthy subjects: Contraindications for receiving an MRI; contraindications for receiving a TMS measurement; more than one seizure per week; missing consent to participate in this study; psychiatric or neurologic diseases
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method umber of resected, functionally-relevant rnTMS stimulation points (points where errors could be elicited during rnTMS stimulation); motor outcome (BMRC score) for upper and lower extremities immediately after surgery
- Secondary Outcome Measures
Name Time Method Incidence of SMA syndrome; finger tapping score; number of names words in verbal fluency task; cookie theft picture task; quality of life (EORTC-BN20); Number of stimulation points in the healthy SMA, where errors in task completion of the ipsilateral extremity could be elicited (compared to preoperative mapping and healthy subjects)