Optimisation of research protocols for respiratory challenges with the RespirAct (RA-MR)TM in healthy volunteers

• Conditions: tissues and organs; 10023213; 10027476; 10007951

• Registration Number: NL-OMON49452
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 80

Inclusion Criteria

- Signed informed consent
- Age: 18-90 years
- Healthy subject (defined as a volunteer who is not referred to Erasmus MC
with signs and symptoms of disease)

Exclusion Criteria

- No informed consent
- Subjects refusing to undergo testing
- Subjects with obstructive or resistive lung disease whose PaCO2 at rest is
greater than 50mmHg or whose venous serum bicarbonate is greater than 26 mEq/L
- Subjects with pre-existing respiratory acidosis
- Subjects who require portable oxygen at rest or with exercise
- Subjects with chronic heart failure or severe pulmonary disease who are
unable to climb one flight of stairs due to shortness of breath
- Subjects with severe heart failure or restrictive lung disease with resting
respiratory rate over 15 breaths/min
- Subjects with a typical contra-indication to an MRI exam
- Subjects with metal implants
- Woman who are pregnant or lactating
- Having any physical or mental status that interferes with the informed
consent procedure

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified