Guiding Hypertension Management Using Different Blood Pressure Monitoring Strategies
- Conditions
- Hypertension
- Interventions
- Device: Home BPDevice: uAOBPDevice: CBP
- Registration Number
- NCT03578848
- Lead Sponsor
- Taipei Veterans General Hospital, Taiwan
- Brief Summary
Patients with uncontrolled or newly diagnosed hypertension will be randomized to have hypertension management decisions made on the basis of the unattended automated blood pressure (uAOBP) , home BP, and central BP monitoring. This study evaluates the optimal guiding strategy for hypertension will help define which BP monitoring is the most effective strategy to guide the clinical management of hypertension.
- Detailed Description
The traditional BP used for clinical practice, the office BP, is usually measured in a busy and hurry clinical environment, and interfered by the well-known confounding whitecoat effect. As such, unattended automated office BP monitoring (uAOBP) has been proposed as an effective solution and further promoted by Canadian physicians.
Nonetheless, out-of-office BP, home BP and ambulatory BP, remains the methodology of recommendation for the detection of whitecoat effect, and its prognostic value has been demonstrated to be superior to the traditional office BP. Home BP monitoring, with its ability to detect morning and masked hypertension and a better tolerability than ambulatory BP monitoring for long-term use, can therefore be considered as a strategy of choice to replace office BP monitoring for guiding hypertension management.
Moreover, BP measurements in the peripheral arteries cannot serve as direct substitutes for their central counterparts because of the long-recognized differences of blood pressure (BP) waveforms and values between the central aorta and peripheral arterial system. Thus, if the decisions on medication adjustment are made solely based brachial BP, there could be a considerable risk of over- or undertreatment.
Considering that there are many better strategies for guiding hypertension management than traditional office BP, there is an apparent need for investigating their comparative effectiveness and safety in the management of hypertension. The investigators hypothesized that home BP may be non-inferior to AOBP and central BP-guided intervention in reducing ambulatory BP and designed the present randomized controlled trial.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 252
- 20 to 90 years of age
- nonpregnant
- receiving antihypertensive therapy for uncomplicated essential hypertension and taking ≥1 but ≤ 2 types antihypertensive drugs (to rule out complicated or resistant hypertension) or hypertension newly diagnosed by uAOBP (uAOBP >130 mmHg at screening visit)
- Poor adherence to medication
- unable to conduct self-measurement blood pressure
- history of polycystic kidney disease
- congestive heart failure (a recent assessment of left ventricular ejection fraction < 40% prior to screening visit)
- chronic kidney disease with estimated glomerular filtration rate < 30 mL/min/1.73m2 (MDRD) at screening visit
- a recent document of severely abnormal left ventricular mass index (>59 g/m2.7 in women and >64 g/m2.7 in men) prior to screening visit
- secondary causes of hypertension
- uncontrolled hypertension (uAOBP >180/100 mm Hg at screening visit)
- history of severe aortic valve disease
- history of upper limb obstructive atherosclerosis
- history of atrial fibrillation
- BP Differences more than 5 mmHg between both arms at screening visit
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description CBP & Home BP Home BP On the scheduled visits, the CBP and Home BP will be measured before meeting doctors and provided for clinicians to adjust patients' medication according to practice guideline. uAOBP & Home BP Home BP On the scheduled visits, the uAOBP and Home BP will be measured before meeting doctors and provided for clinicians to adjust patients' medication according to practice guideline. uAOBP & Home BP uAOBP On the scheduled visits, the uAOBP and Home BP will be measured before meeting doctors and provided for clinicians to adjust patients' medication according to practice guideline. CBP & Home BP CBP On the scheduled visits, the CBP and Home BP will be measured before meeting doctors and provided for clinicians to adjust patients' medication according to practice guideline.
- Primary Outcome Measures
Name Time Method 24 hour mean ambulatory systolic blood pressure 3 months The change of 24 hour mean ambulatory systolic blood pressure (SBP)
- Secondary Outcome Measures
Name Time Method left ventricular mass 12 months decrease of left ventricular mass
24 hour mean ambulatory diastolic blood pressure 3 months The change of 24 hour mean ambulatory diastolic blood pressure (DBP)
SBP and DBP 12 months change of SBP/DBP measured by uAOBP monitoring, home BP monitoring, or central BP monitoring
Trial Locations
- Locations (1)
Taipei Veterans General Hospital
🇨🇳Taipei, Taiwan