Clinical Evaluation of the Effectiveness of Immediate Relief Obtained With Desensitizing Creams - A Controlled, Randomized, Triple Masked, Split-Mouth Clinical Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 138
- 试验地点
- 2
- 主要终点
- cervical dentin hypersensitivity
研究概览
简要总结
The aim of this study was to evaluate the efficacy of three desensitizing toothpastes for immediate and intermediate-term relief of CDH, when compared with a control toothpaste. One hundred and thirty-eight hypersensitive teeth were diagnosed and randomized into four groups according to the therapeutic agent of each desensitizing cream tested: 1) strontium acetate and calcium carbonate, 2) calcium carbonate and arginine 8%, 3) calcium phosphate nanoparticles and 4) a control toothpaste. The desensitizing creams were applied according to the manufacturer's instructions. Cervical dentin hypersensitivity was assessed at baseline, immediately, 24 hours and 30 days after the treatment. Cold and evaporative tests were used to assess the sensitivity level.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 22 Years 至 48 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •subjects 18 years or older
- •in good general and oral health; have complaint of CDH in teeth distributed in all 4 quadrants
- •not making use of desensitizing agents
- •not having undergone periodontal treatment over the past 3 months
- •respond to evaporative stimulus with a score ≥ 1.5 cm on VAS
排除标准
- •patients who presented restorations and caries near the exposed dentin of the hypersensitive teeth
- •who made frequent use of painkillers, anti-inflammatory and antidepressants drugs
结局指标
主要结局
cervical dentin hypersensitivity
时间窗: 30 days
The cervical dentin hypersensitivity was evaluated by an air blast (evaporative stimulus) for 5 seconds, and by a tetrafluoroethane spray (cold stimulus) for 5 seconds.
次要结局
未报告次要终点
研究者
Olga Flecha
PhD
Federal University of São Paulo