Performance of Endoscopic and Histological Criteria of Atrophic Gastritis and Intestinal Metaplasia in Predicting Risk of Gastric Cancer - a Multicenter Case Control Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Gastric Cancer
- Sponsor
- Chinese University of Hong Kong
- Enrollment
- 400
- Locations
- 4
- Primary Endpoint
- Operative links on gastritis assessment (OLGA)
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
This is a multi-center prospective case control study aiming to compare different methods of risk stratification models in predicting the risk of gastric cancer development.
Detailed Description
The case control study would compare which type of assessment (Endoscopic / histological) is more accurate in predicting the risk of gastric cancer development. The risk factor assessment would be based on the following criteria. Endoscopic assessment: 1. Atrophic gastritis, based on Kimura Takemoto Classification 2. Kyoto classification of gastritis 3. Intestinal metaplasia, based on Endoscopic Mapping and Grading of Intestinal Metaplasia (EGGIM) Histological assessment (Based on random biopsies) 1. Operative Links on Gastritis Assessment 2. Operative Links on Gastric Intestinal Metaplasia
Investigators
Hon Chi Yip
Associate Consultant
Chinese University of Hong Kong
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Operative links on gastritis assessment (OLGA)
Time Frame: Cross sectional study, day 0
Biopsy based risk stratification panel based on severity of atrophic gastritis
Operative links on gastric intestinal metaplasia (OLGIM)
Time Frame: Cross sectional study, day 0
Biopsy based risk stratification panel based on severity of intestinal metaplasia
Endoscopic grading of intestinal metaplasia (EGGIM)
Time Frame: Cross sectional study, day 0
Endoscopic mapping of degree of intestinal metaplasia
Endoscopic grading of atrophic gastritis (Kimura Takemoto Classification)
Time Frame: Cross sectional study, day 0
Endoscopic description of severity of gastric atrophy
Kyoto classification of gastritis
Time Frame: Cross sectional study, day 0
Descriptive findings of gastritis