Performance of Endoscopic and Histological Criteria of Atrophic Gastritis and Intestinal Metaplasia in Predicting Risk of Gastric Cancer - a Multicenter Case Control Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 400
- 试验地点
- 4
- 主要终点
- Operative links on gastritis assessment (OLGA)
研究概览
简要总结
This is a multi-center prospective case control study aiming to compare different methods of risk stratification models in predicting the risk of gastric cancer development.
详细描述
The case control study would compare which type of assessment (Endoscopic / histological) is more accurate in predicting the risk of gastric cancer development.
The risk factor assessment would be based on the following criteria.
Endoscopic assessment:
-
Atrophic gastritis, based on Kimura Takemoto Classification
-
Kyoto classification of gastritis
-
Intestinal metaplasia, based on Endoscopic Mapping and Grading of Intestinal Metaplasia (EGGIM) Histological assessment (Based on random biopsies)
-
Operative Links on Gastritis Assessment 2. Operative Links on Gastric Intestinal Metaplasia
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 40 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Operative links on gastritis assessment (OLGA)
时间窗: Cross sectional study, day 0
Biopsy based risk stratification panel based on severity of atrophic gastritis
Operative links on gastric intestinal metaplasia (OLGIM)
时间窗: Cross sectional study, day 0
Biopsy based risk stratification panel based on severity of intestinal metaplasia
Endoscopic grading of intestinal metaplasia (EGGIM)
时间窗: Cross sectional study, day 0
Endoscopic mapping of degree of intestinal metaplasia
Endoscopic grading of atrophic gastritis (Kimura Takemoto Classification)
时间窗: Cross sectional study, day 0
Endoscopic description of severity of gastric atrophy
Kyoto classification of gastritis
时间窗: Cross sectional study, day 0
Descriptive findings of gastritis
次要结局
未报告次要终点
研究者
Hon Chi Yip
Associate Consultant
Chinese University of Hong Kong