GABA, excitability and plasticity in the human motor cortex, an explorative study

Completed

• Conditions: niet van toepassing; not applicable

• Registration Number: NL-OMON37805
• Lead Sponsor: Radboud Universiteit Nijmegen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 24

Inclusion Criteria

healthy, right-handed partcipants (males and females). Age 18-35 years.

Exclusion Criteria

Contra-indications for TMS and fMRI: drug abuse, head trauma, neurological or psychiatric illness, pregnancy, heart disease, claustrophobia, cardiac pacemakers, metal objects in the body, medication pumps, tricyclic antidepressants, neuroleptics and a familiy history of neurological illness or epilepsy.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>MEP and SICI amplitudes are measured using EMG, resting-state connectivity<br /><br>(RSC) is indexed by analyzing rs-fMRI and GABA concentration is determined<br /><br>using MR spectroscopy. The modulation of these measurements by rTMS will inform<br /><br>us on the mechanistic relationship between GABA, excitability and plasticity in<br /><br>the primary motor cortex.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>not applicable</p><br>