NCT01744769Unknown不适用
Effects of Thyroid Hormone Withdrawal on Metabolic and Cardiovascular Parameters During Radioactive Iodine Therapy in Differentiated Thyroid Cancer
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Changes of metabolic parameters
研究概览
简要总结
- The incidence of differentiated thyroid cancer is increasing in Korea. A significant number of them experience severe hypothyroidism in preparation for radioactive iodine (RAI) therapy after total thyroidectomy.
- Because the function of thyroid hormone is closely linked with lipid and glucose metabolism, overt hypothyroidism after thyroid hormone withdrawal during RAI therapy may induce the changes of metabolic parameters.
- We investigate the effects of thyroid hormone withdrawal on metabolic and cardiovascular parameters during radioactive iodine therapy in differentiated thyroid cancer.
详细描述
-
Study design measurement of various parameters during hypothyroid state (before 1 month, the day and after 1 month of RAI therapy)
-
Measurements
-
Measurement of metabolic and cardiovascular parameters
- glucose profiles : HbA1c, fasting glucose level
- lipid profiles : free fatty acid, total, LDL-, HDL-, cholesterol, triglyceride
- adipocytokines : retinol binding protein(RBP)
- 4, leptin, resistin, adiponectin
- markers of endothelial and cardiac function : high-sensitivity C-reactive protein(hsCRP), homocystein, B-type natriuretic peptide(BNP)
- bone turnover markers : CTX, bone ALP
- Scoring of symptoms and signs of hypothyroidism (Zulewski score)
- symptoms
- physical signs
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •radioiodine therapy after total thyroidectomy in differentiated thyroid cancer
- •age over 18
排除标准
- •kidney failure, liver failure, heart failure
- •infection
- •inflammation
- •autoimmune disease
- •other chronic disease
结局指标
主要结局
Changes of metabolic parameters
时间窗: Before 1month of radioiodine therapy, Day of radioiodine therapy, After 1 month of radioiodine therapy
* glucose profiles : HbA1c, fasting glucose level * lipid profiles : free fatty acid, total, LDL-, HDL-, cholesterol, triglyceride * adipocytokines : retinol binding protein(RBP)4, leptin, resistin, adiponectin * markers of endothelial and cardiac function : high-sensitivity C-reactive - protein(hsCRP), homocystein, B-type natriuretic peptide(BNP)
次要结局
- Changes of bone turnover markers(Before 1month of radioiodine therapy, Day of radioiodine therapy, After 1 month of radioiodine terapy)
研究者
Suk Kyeong Kim
Associate professor
Konkuk University Medical Center
研究点 (1)
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