The Utility of Thromboelastography for Predicting the Risk of Coagulation-Related Damages Secondary to Traumatic Brain Injury
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Traumatic Brain Injury
- Sponsor
- Shanghai 6th People's Hospital
- Enrollment
- 500
- Locations
- 1
- Primary Endpoint
- Glasgow Outcome Scale scores
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
Hemocoagulation disorder is recognized to have crucial effects on hemorrhagic or ischemic diseases. Coagulation-related damages secondary to traumatic brain injury are common and severe secondary insults of head trauma and often leads to a poor prognosis. In this study, we sought to assess if posttraumatic hemocoagulation disorders determined using thromboelastography are associated with coagulation-related damages secondary to traumatic brain injury, and evaluate their influence on outcome among patients with head trauma. Based on above results, prediction models or risk scoring systems will be further developed and validated to predict coagulation-related damages secondary to traumatic brain injury.
Investigators
Hao Chen, MD, PhD
Associate Clinical Professor
Shanghai 6th People's Hospital
Eligibility Criteria
Inclusion Criteria
- •Patients who are delivered to hospital within 24 hours after head trauma
- •Patients whose abbreviated injury score (AIS) for other body regions is 3 or less are considered to be isolated traumatic brain injury
Exclusion Criteria
- •Patients with existing prior neurological disease
- •Patients with known coagulation disorders
- •Patients on anticoagulants and medications known to affect coagulation function within 30 days before trauma
- •Patients receiving blood components prior to blood draw
- •Patients who deteriorate and die before determining whether coagulation- related damage exists
Outcomes
Primary Outcomes
Glasgow Outcome Scale scores
Time Frame: Six months
Glasgow Outcome Scale 1 = death; Glasgow Outcome Scale 2 = vegetative state; Glasgow Outcome Scale 3 = severe neurological deficit; Glasgow Outcome Scale 4 = mild neurological deficit and Glasgow Outcome Scale 5 = premorbid level of functioning or completely recovery. Unfavorable outcome is defined as a Glasgow Outcome Scale score of ≤ 3, and favorable outcome is defined as a Glasgow Outcome Scale score of \> 3.