临床试验/CTRI/2024/07/070187

CTRI/2024/07/070187招募中不适用

Neurophysiology and Imaging Measures in Predicting Motor Outcome of Motor Eloquent Glioma Surgery

National Institute of Mental Health and Neurosciences1 个研究点分布在 1 个国家目标入组 34 人开始时间: 2024年8月1日最近更新: 2024年7月3日

试验速览

阶段: 不适用
状态: 招募中
发起方: National Institute of Mental Health and Neurosciences
入组人数: 34
试验地点: 1
主要终点: Predicting motor outcome of brain tumor glioma surgery using different neurophysiological parameters(TMS and IONM)

研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

The brain tumor is an abnormal growth of cells within the brain or central nervous system

These tumors can be benign (noncancerous) or malignant (cancerous)

To evaluate the utility of various neurophysiological parameters including IONM, TMS and neural connectivity (functional connectivity- EEG, structural connectivity- DTI/MRI) as an effective predictive measure of motor outcome in glioma surgery involving the motor eloquent region.

研究设计

研究类型: Observational

入排标准

年龄范围: 20.00 Year(s) 至 60.00 Year(s)（—）
性别: All

入选标准

•Clinically confirmed cases of gliomas involving motor eloquent and perirolandic regions Patient willing to participate in the study and give informed written consent.

排除标准

•Patients with MRC motor power scale less than 2 will be excluded Patients with advanced symptoms of neurological cardio and respirator complications Patients with other neurological conditions such muscular dystrophies Parkinsonism Alzheimers and other metabolic disorders Patients with evidence of any other malignancy Patients with contraindications to TMS.

结局指标

主要结局

Predicting motor outcome of brain tumor glioma surgery using different neurophysiological parameters(TMS and IONM)

时间窗: baseline (Preoperative) | During Surgery (Intraoperative) | 1-2 weeks after surgery (Postoperative)

次要结局

Predicting motor outcome of brain tumor glioma surgery using different neurophysiological parameters(HRV, EEG & DTI)(baseline (Preoperative))

研究者

发起方

National Institute of Mental Health and Neurosciences

申办方类型

Research institution and hospital

责任方

Principal Investigator

主要研究者

Dr Sathyaprabha TN

National Institute of Mental Health and Neurosciences

研究点 (1)

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