Analysis of risk factors in patients with recurrent pregnancy loss and implantation failure

Recruiting

• Conditions: N96; N97.9; Habitual aborter; Female infertility, unspecified

• Registration Number: DRKS00020803
• Lead Sponsor: Medizinische Universität Innsbruck

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-02-25
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Female
• Target Recruitment: 900

Inclusion Criteria

RSA:
The study includes all patients who have suffered at least two consecutive miscarriages and for whom standardized diagnostics will be carried out as part of the miscarriage consultation.

RIF:
The study includes all patients who were diagnosed with an RIF in accordance with the criteria specified in the study protocol during the fertility consultation and who were diagnosed with regard to the above. Risk factors are carried out.

Control group:
As a control group, a group of healthy, non-pregnant women without hormonal contraception between 20 and 40 years old, without existing pregnancies, without Z.n. Blood transfusions, without existing autoimmune diseases or regular medication, which are treated in the fertility clinic of the Clinic for Gynecological Endocrinology and Reproductive Medicine due to a male fertility restriction. A second control group consists of a group of women who have already had one or more successful pregnancies without a history of miscarriages and who are treated as part of contraceptive counseling.

Exclusion Criteria

In order to obtain a comparable study collective, all patients for whom the complete diagnostics are not carried out are excluded from the study. Patients who cancel the diagnosis during the examination period are excluded from the study.

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Subpopulations of T-cells, regulatory T-cells, B-cells and NK-cells in patients with RM and RIF

Secondary Outcome Measures

Name	Time	Method
prevalence of the following Risk factors for RM and RIF:<br>a) anatomic anomalies of the uterus<br>o Uterus septus<br>o myomas<br>o Intracavitary synechies<br>o Intracavitary polyps<br><br>b) hemostaseology<br>o Faktor II Mutation<br>o Faktor V Leiden Mutation<br>o Protein-S/C-deficiency<br>o Antithrombin III deficiency<br><br>c) endocrinology<br>o Diabetes mellitus<br>o Hypothyreosis<br>o Hyperprolaktinaemia<br>o luteal Phase deficiency<br><br>d) numeric und structural chromosomal aberrations <br><br>e) Immunology<br>o Antiphospholipid-syndrome<br>o Autoimmune auto-antibodies<br><br>f) Smoking (cig/day)