Electrical Muscle Stimulation in the Development of Acquired Weakness in the Intensive Care Unit in Adult Patients With Severe Sepsis and Septic Shock at the Clinic Hospital of the Univerisity of Chile: Results of a Pilot Randomized Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Polyneuropathies
- Sponsor
- University of Chile
- Enrollment
- 23
- Primary Endpoint
- intensive care unit acquired weakness
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
The aim of this study is to compare the effect of EMS and conventional physical therapy on strength and muscle mass and development in adult patients with severe sepsis and septic shock.
Detailed Description
Septic patients are at high risk of developing intensive care unit acquired weakness (ICUAW). Electrical muscle stimulation (EMS) has become an alternative exercise for critical and non-cooperative patients.
Investigators
daniel arellano sepulveda
principal investigator
University of Chile
Eligibility Criteria
Inclusion Criteria
- •Subjects admitted to the ICU of the HCUCH in the period between November 2016 to August 2017 and January to June 2018
- •Diagnosis of severe sepsis or septic shock
- •More than 48 hours in VMI
- •With sedation and / or neuromuscular blockade
- •Autovalent prior to admission to the ICU
Exclusion Criteria
- •Subjects from other hospitals / clinics or units of the hospital
- •Multiple trauma
- •Previous neuromuscular pathology
- •Pacemaker users
- •Pregnant women
- •Those who have refused to sign informed consent
Outcomes
Primary Outcomes
intensive care unit acquired weakness
Time Frame: at awakening of the subject, an average of 8 days
Medical research council sum score: Bilateral testing of 6 muscle groups (shoulder abduction, elbow flexion, wrist extension, hip flexion, knee extension, and ankle dorsiflexion). Ranges from 0 (total paralysis) to 60 (normal strength). Score under 48 points indicates intensive care unit acquired weakness
Secondary Outcomes
- muscle mass(at ICU admission of the subjet, at 48 hours post admission and at awakening of the subject, an average of 8 days)
- days of ICU stay(at ICU discharge, an average of 18 days)
- mortality at 28 days(at 28 days post ICU admission)
- muscle strength(at awakening of the subject, an average of 8 days)
- maximum inspiratory pressure(at awakening of the subject, an average of 8 days)
- days of mechanical ventilation(an average of 11 days)
- Number of Participants with weaning failure(48 hours post extubation day)
- gait ability at hospital discharge(at hospital discharge, an averange of 3 months)