Electrical Muscle Stimulation in the Development of Acquired Weakness in Patients With Severe Sepsis and Septic Shock
- Conditions
- Septic ShockPolyneuropathiesMuscle Weakness
- Registration Number
- NCT03765489
- Lead Sponsor
- University of Chile
- Brief Summary
The aim of this study is to compare the effect of EMS and conventional physical therapy on strength and muscle mass and development in adult patients with severe sepsis and septic shock.
- Detailed Description
Septic patients are at high risk of developing intensive care unit acquired weakness (ICUAW). Electrical muscle stimulation (EMS) has become an alternative exercise for critical and non-cooperative patients.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 23
- Subjects admitted to the ICU of the HCUCH in the period between November 2016 to August 2017 and January to June 2018
- Diagnosis of severe sepsis or septic shock
- More than 48 hours in VMI
- With sedation and / or neuromuscular blockade
- Autovalent prior to admission to the ICU
- Subjects from other hospitals / clinics or units of the hospital
- Multiple trauma
- Previous neuromuscular pathology
- Pacemaker users
- Pregnant women
- BMI> 35
- Epilepsy
- Those who have refused to sign informed consent
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method intensive care unit acquired weakness at awakening of the subject, an average of 8 days Medical research council sum score: Bilateral testing of 6 muscle groups (shoulder abduction, elbow flexion, wrist extension, hip flexion, knee extension, and ankle dorsiflexion). Ranges from 0 (total paralysis) to 60 (normal strength). Score under 48 points indicates intensive care unit acquired weakness
- Secondary Outcome Measures
Name Time Method days of ICU stay at ICU discharge, an average of 18 days number of days in ICU
muscle strength at awakening of the subject, an average of 8 days Medical research council sum score: Bilateral testing of 6 muscle groups (shoulder abduction, elbow flexion, wrist extension, hip flexion, knee extension, and ankle dorsiflexion). Ranges from 0 (total paralysis) to 60 (normal strength).
maximum inspiratory pressure at awakening of the subject, an average of 8 days maximum inspiratory pressure
days of mechanical ventilation an average of 11 days number of days wirh mechanical ventilation
Number of Participants with weaning failure 48 hours post extubation day Number of Participants who presented reintubation
gait ability at hospital discharge at hospital discharge, an averange of 3 months presence or not of gait ability
muscle mass at ICU admission of the subjet, at 48 hours post admission and at awakening of the subject, an average of 8 days ultrasonography
mortality at 28 days at 28 days post ICU admission mortality