Effect of sivelestat, a neutrophil elastase inhibitor on cardiac surgical patients after cardiopulmonary bypass - Effect of sivelestat, a neutrophil elastase inhibitor on cardiac surgical patients after cardiopulmonary bypass

In the control group, the levels of PMN elastase, IL-6, IL-8 in BAL showed a increase after CPB initiation, and were maintained at high levels 3 hours after CPB. In contrast, the sivelestat group had lower concentrations of PMN elastase, IL-6, IL-8 during and after CPB. The reduction in PaO2/FiO2 ratio after CPB was strongly related to the increase in IL-8, IL-6 or the elevation in PMN elastase.