Acute High-risk Abdominal Surgery Study - an Optimized Perioperative Course
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1,200
- 试验地点
- 1
- 主要终点
- mortality rate
研究概览
简要总结
The objective of this study is to implement an optimized perioperative course for patients undergoing acute high-risk abdominal surgery in order to improve the outcome.
The optimized perioperative course consists of a number of interventions carried out before, during and after surgery.
详细描述
Emergency surgery is associated with high mortality rates, post-operative complications and prolonged duration of hospital admission. The investigators will implement a multidisciplinary optimized perioperative course consisting of a number of interventions carried out before, during and after surgery.
Hypothesis
An optimized perioperative course will reduce the 30-day mortality in emergency abdominal surgery patients.
The investigators will do a post-hoc analysis of the data registered.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients undergoing primary emergency laparotomy or laparoscopy
- •patients undergoing reoperation after abdominal surgery.
- •Age > 18 years
排除标准
- •Appendectomy
- •Emergency laparoscopic cholecystectomy
- •Emergency diagnostic laparoscopy without intervention
研究组 & 干预措施
historic control group
Standard treatment in the historic control group
Intervention group
AHA (Acute Highrisk Abdominalsurgery): Optimized Course:
Intervention before, during and after abdominal surgery.
Focus on fast track with multimodal standardized intervention:
- standardized preparing for surgery including high dose antibiotics and epidural analgesia etc. and transfer to intermediate care before surgery (the post-anaesthesia care unit)
- GDT-LiDCO fluid management pre-, per- and postoperative
- Postoperative triage to 24 hour intermediate care based on ASA score and Surgical Apgar Score
- Focus on early mobilization, fysiotherapy and optimal nutrition postoperatively
干预措施: AHA (Acute Highrisk Abdominalsurgery): Optimized Course (Procedure)
结局指标
主要结局
mortality rate
时间窗: Within 30 days of surgery
次要结局
未报告次要终点
研究者
Line Toft Tengberg
MD
Hvidovre University Hospital